Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element

Fischer, Anne, Liljander, Anne, Kaspar, Heike, Muriuki, Cecilia, Fuxelius, Hans-Henrik, Bongcam-Rudloff, Erik, de Villiers, Etienne P ., Huber, Charlotte A ., Frey, Joachim, Daubenberger, Claudia, Bishop, Richard, Younan, Mario and Jores, Joerg (2013) Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element. Veterinary Research, 44 86: 1-10. doi:10.1186/1297-9716-44-86


Author Fischer, Anne
Liljander, Anne
Kaspar, Heike
Muriuki, Cecilia
Fuxelius, Hans-Henrik
Bongcam-Rudloff, Erik
de Villiers, Etienne P .
Huber, Charlotte A .
Frey, Joachim
Daubenberger, Claudia
Bishop, Richard
Younan, Mario
Jores, Joerg
Title Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element
Formatted title
Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element
Journal name Veterinary Research   Check publisher's open access policy
ISSN 0928-4249
1297-9716
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1186/1297-9716-44-86
Open Access Status DOI
Volume 44
Issue 86
Start page 1
End page 10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2014
Language eng
Formatted abstract
Camels are the most valuable livestock species in the Horn of Africa and play a pivotal role in the nutritional sustainability for millions of people. Their health status is therefore of utmost importance for the people living in this region. Streptococcus agalactiae, a Group B Streptococcus (GBS), is an important camel pathogen. Here we present the first epidemiological study based on genetic and phenotypic data from African camel derived GBS. Ninety-two GBS were characterized using multilocus sequence typing (MLST), capsular polysaccharide typing and in vitro antimicrobial susceptibility testing. We analysed the GBS using Bayesian linkage, phylogenetic and minimum spanning tree analyses and compared them with human GBS from East Africa in order to investigate the level of genetic exchange between GBS populations in the region. Camel GBS sequence types (STs) were distinct from other STs reported so far. We mapped specific STs and capsular types to major disease complexes caused by GBS. Widespread resistance (34%) to tetracycline was associated with acquisition of the tetM gene that is carried on a Tn916-like element, and observed primarily among GBS isolated from mastitis. The presence of tetM within different MLST clades suggests acquisition on multiple occasions. Wound infections and mastitis in camels associated with GBS are widespread and should ideally be treated with antimicrobials other than tetracycline in East Africa.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 19 Mar 2014, 14:43:53 EST by Ms Charlotte Huber on behalf of UQ Centre for Clinical Research