1. Exome sequence data of oral squamous cell carcinomas from 44 young (< 45 yo) and old (≥ 45 yo) patients.
2. Exome sequence data of 50 samples from both pre-oral cancer patients that have progressed to cancer (progressive cohort) and pre-oral cancer patients that have not (> 5 years) progressed to oral cancer.
3. Transcriptome data from oral cancer and pre-cancer cell lines.
4. Transcriptome data from oral pre-cancer surgical margins.
5. Transcriptome data from oral cancer and precancerous lesions.
The significance of the data truly lies in the uniqueness of the collected sequenced samples over the last 50 years. Archival tissues, collected over the past 50 years both in the form of formalin fixed paraffin embedded and fresh frozen tissues, have allowed us to design experiments to answer questions regarding the genetic contribution to the development of oral cancer and the underlying genomic changes that dictate progression to oral cancer from a precursor lesion.
Data consists of Applied Biosystems 5500XL sequencing machine output files.