Hydrogels containing silver nanoparticles for burn wounds show antimicrobial activity without cytotoxicity

Boonkaew, Benjawan, Suwanpreuksa, Pimpa, Cuttle, Leila, Barber, Philip Martin and Supaphol, Pitt (2014) Hydrogels containing silver nanoparticles for burn wounds show antimicrobial activity without cytotoxicity. Journal of Applied Polymer Science, 131 9: . doi:10.1002/app.40215


Author Boonkaew, Benjawan
Suwanpreuksa, Pimpa
Cuttle, Leila
Barber, Philip Martin
Supaphol, Pitt
Title Hydrogels containing silver nanoparticles for burn wounds show antimicrobial activity without cytotoxicity
Journal name Journal of Applied Polymer Science   Check publisher's open access policy
ISSN 0021-8995
1097-4628
Publication date 2014-05-05
Year available 2013
Sub-type Article (original research)
DOI 10.1002/app.40215
Open Access Status
Volume 131
Issue 9
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2014
Language eng
Formatted abstract
This research introduces a novel dressing for burn wounds, containing silver nanoparticles in hydrogels for infected burn care. The 2-acrylamido-2-methylpropane sulfonic acid sodium salt hydrogels containing silver nanoparticles have been prepared via ultraviolet radiation. The formation of silver nanoparticles was monitored by surface plasmon bands and transmission electron microscopy. The concentration of silver nitrate loaded in the solutions slightly affected the physical properties and mechanical properties of the neat hydrogel. An indirect cytotoxicity study found that none of the hydrogels were toxic to tested cell lines. The measurement of cumulative release of silver indicated that 70%-82% of silver was released within 72 hr. The antibacterial activities of the hydrogels against common burn pathogens were studied and the results showed that 5 mM silver hydrogel had the greatest inhibitory activity. The results support its use as a potential burn wound dressing.
Keyword Antimicrobial activity
Hydrogels
Hydrophilic polymers
Irradiation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 40215. Published online ahead of print 30 November 2013.

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 18 Mar 2014, 00:10:37 EST by System User on behalf of Child Health Research Centre