Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

Forbes, Josephine M., Sourris, Karly C., de Courten, Maximilian P. J., Dougherty, Sonia L., Chand, Vibhasha, Lyons, Jasmine G., Bertovic, David, Coughlan, Melinda T., Schlaich, Markus P., Soldatos, Georgia, Cooper, Mark E., Straznicky, Nora E., Kingwell, Bronwyn A. and de Courten, Barbora (2013) Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects. Amino Acids, 46 2: 321-326. doi:10.1007/s00726-013-1542-9


Author Forbes, Josephine M.
Sourris, Karly C.
de Courten, Maximilian P. J.
Dougherty, Sonia L.
Chand, Vibhasha
Lyons, Jasmine G.
Bertovic, David
Coughlan, Melinda T.
Schlaich, Markus P.
Soldatos, Georgia
Cooper, Mark E.
Straznicky, Nora E.
Kingwell, Bronwyn A.
de Courten, Barbora
Title Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects
Journal name Amino Acids   Check publisher's open access policy
ISSN 0939-4451
1438-2199
Publication date 2013
Year available 2013
Sub-type Fully published paper
DOI 10.1007/s00726-013-1542-9
Open Access Status
Volume 46
Issue 2
Start page 321
End page 326
Total pages 6
Place of publication Vienna, Austria
Publisher Springer Wien
Collection year 2014
Language eng
Subject 1605 Policy and Administration
1308 Clinical Biochemistry
1303 Specialist Studies in Education
Abstract It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m2). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p < 0.05) and lower 2-h glucose concentrations during OGTT (r = -0.31; p < 0.05). In addition, fasting (r = -0.36; p < 0.05) and 2-h glucose concentrations were negatively related to circulating levels of soluble receptor for AGE (RAGE) isoforms (r = -0.39; p < 0.01). In conclusion, in healthy humans, we show a cross-sectional association between advanced glycation end products and acute insulin secretion during glucose tolerance testing.
Keyword Central obesity
Insulin secretion
Insulin sensitivity
Type 2 diabetes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Fully published paper
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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