Immunopathogenesis of ankylosing spondylitis

Kenna, Tony J. and Brown, Matthew A. (2013) Immunopathogenesis of ankylosing spondylitis. International Journal of Clinical Rheumatology, 8 2: 265-274. doi:10.2217/ijr.12.84

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Author Kenna, Tony J.
Brown, Matthew A.
Title Immunopathogenesis of ankylosing spondylitis
Journal name International Journal of Clinical Rheumatology   Check publisher's open access policy
ISSN 1758-4272
Publication date 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/ijr.12.84
Open Access Status
Volume 8
Issue 2
Start page 265
End page 274
Total pages 10
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2014
Abstract Ankylosing spondylitis is a model immunogenetic disease with major common and rare genetic risk factors, likely environmental contributors to its pathogenesis and, to date, no treatment that has been shown to induce disease remission in long-term studies. The discovery of the association of HLA-B27 with the disease in the early 1970s triggered extensive efforts to elucidate the mechanism of this association. However, the precise role of HLA-B27 in ankylosing spondylitis pathogenesis remains unclear. In recent years, rapid progress made in the discovery of non-MHC genes involved in susceptibility to ankylosing spondylitis has combined with increasing ability to investigate the immune system to make rapid progress in unraveling the etiopathogenesis of the condition.
Keyword Ankylosing spondylitis
Antigen processing
Innate immunity
T cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
UQ Diamantina Institute Publications
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Created: Fri, 14 Mar 2014, 09:22:57 EST by Kylie Hengst on behalf of UQ Diamantina Institute