Obesity, the PI3K/Akt signal pathway and colon cancer

Huang, X-F. and Chen, J-Z. (2009) Obesity, the PI3K/Akt signal pathway and colon cancer. Obesity reviews, 10 6: 610-616. doi:10.1111/j.1467-789X.2009.00607.x

Author Huang, X-F.
Chen, J-Z.
Title Obesity, the PI3K/Akt signal pathway and colon cancer
Journal name Obesity reviews   Check publisher's open access policy
ISSN 1467-789X
Publication date 2009-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1467-789X.2009.00607.x
Open Access Status
Volume 10
Issue 6
Start page 610
End page 616
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Obesity is currently reaching epidemic levels worldwide and is a major predisposing factor for a variety of life-threatening diseases including diabetes, hypertension and cardiovascular diseases. Recently, it has also been suggested to be linked with cancer.

Epidemiological studies have shown that obesity increases the risk of colon cancer by 1.5–2 fold with obesity-associated colon cancer accounting for 14–35% of total incidence. Several factors, altered in obesity, may be important in cancer development including increased levels of blood insulin, insulin-like growth factor I, leptin, TNF-α, IL-6 as well as decreased adiponectin. A unifying characteristic of all these factors is that they increase the activity of the PI3K/Akt signal pathway. The PI3K/Akt signal pathway in turn activates signals for cell survival, cell growth and cell cycle leading to carcinogenesis. Here we review the evidence that PI3K/Akt and its downstream targets are important in obesity-associated colon cancer and thus, that targeted inhibition of this pathway could be employed for the prevention of obesity-associated colon cancer and incorporated into the therapy regime for those with irremovable colon cancers.
Keyword Carcinogenesis
Colon cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 94 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 13 Mar 2014, 14:05:40 EST by Jiezhong Chen on behalf of School of Biomedical Sciences