Influenza virus antigenic variation, host antibody production and new approach to control epidemics

Chen, Jiezhong and Deng, Yi-Mo (2009) Influenza virus antigenic variation, host antibody production and new approach to control epidemics. Virology Journal, 6 March: . doi:10.1186/1743-422X-6-30


Author Chen, Jiezhong
Deng, Yi-Mo
Title Influenza virus antigenic variation, host antibody production and new approach to control epidemics
Journal name Virology Journal   Check publisher's open access policy
ISSN 1743-422X
Publication date 2009-03-13
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1743-422X-6-30
Open Access Status DOI
Volume 6
Issue March
Total pages 3
Place of publication London, United Kingdom
Publisher BioMed
Language eng
Formatted abstract
Influenza is an infectious disease and can lead to life-threatening complications like pneumonia. The disease is caused by three types of RNA viruses called influenza types A, B and C, each consisting of eight negative single-stranded RNA-segments encoding 11 proteins. Current annual vaccines contain two type A strains and one type B strain and are capable of inducing strong antibody responses to both the surface glycoprotein hemagglutinin and the neuraminidase. While these
vaccines are protective against vaccine viruses they are not effective against newly emerging viruses that contain antigenic variations known as antigenic drift and shift. In nature, environmental selection pressure generally plays a key role in selecting antigenic changes in the antigen determining spots of hemagglutinin, resulting in changes in the antigenicity of the virus. Recently, a new technology has been developed where influenza-specific IgG+ antibody-secreting plasma cells
can be isolated and cloned directly from vaccinated humans and high affinity monoclonal antibodies can be produced within several weeks after vaccination. The new technology holds great promise for the development of effective passive antibody therapy to limit the spread of influenza viruses in a timely manner.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article number 30.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 13 Mar 2014, 13:56:24 EST by Jiezhong Chen on behalf of School of Biomedical Sciences