Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells

Chen, Jiezhong and Liu, Xiao Song (2009) Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells. Journal of Leukocyte Biology, 86 6: 1305-1310. doi:10.1189/jlb.0609406


Author Chen, Jiezhong
Liu, Xiao Song
Title Development and function of IL-10 IFN-gamma-secreting CD4(+) T cells
Formatted title
Development and function of IL-10 IFN-γ-secreting CD4+ T cells
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
1938-3673
Publication date 2009-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1189/jlb.0609406
Open Access Status
Volume 86
Issue 6
Start page 1305
End page 1310
Total pages 6
Place of publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Language eng
Formatted abstract
IL-10 IFN-γ-secreting CD4+ T cells were first found in the early 1990s. They are suppressive T cells able to inhibit cytotoxic T lymphocytes. These cells (Foxp3–T bet+) have a similar function but are distinct from conventional Tregs. The production of IL-10 in these cells requires IL-27 and TGF-β and was regulated by several signal pathways including Notch, STAT, and NF-κB. The crosstalk among these pathways is critical for the generation and function of these cells. IL-10 IFN-γ-secreting CD4+ T cells are activated in chronic infection and are responsible for prolonged infection. Thus, their modulation has therapeutic implications for the treatment of infectious diseases. However, it is complicated, and fine-tuning of IFN-γ and IL-10 secretion by these cells is needed for disease management, as inhibition of these cells will also lead to overimmune responses. On the other hand, increasing their numbers in autoimmune diseases may have beneficial effects.
Keyword IL-27
Transcription factors
Infection
Autoimmune disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 13 Mar 2014, 13:45:51 EST by Jiezhong Chen on behalf of School of Biomedical Sciences