Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer

Chen, Jiezhong, Huang, Xu-Feng and Katsifis, Andrew (2010) Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer. Journal of Cellular Biochemistry, 111 5: 1082-1086. doi:10.1002/jcb.22905


Author Chen, Jiezhong
Huang, Xu-Feng
Katsifis, Andrew
Title Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer
Journal name Journal of Cellular Biochemistry   Check publisher's open access policy
ISSN 0730-2312
1097-4644
Publication date 2010-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jcb.22905
Volume 111
Issue 5
Start page 1082
End page 1086
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Colorectal cancer is the third most common cancer with a 5-year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal cancer suggesting anti-EGFR therapy may be a potential treatment option. However, in other cases it is not effective, which may be related to its down-stream targeted gene mutations. KRAS is highly emphasized in the literature but other mutations like Src, PIK3CA, and BRAF may also be important. Furthermore, obesity may decrease the effectiveness of anti-EGFR treatment as it increases the risk factors for colorectal cancer. Using next-generation sequencing technology, it may be possible to identify all gene mutations in an individual with colorectal cancer. Therefore, gene mutations affecting anti-EGFR therapy in colorectal cancer patients can be identified.
Keyword EGFR
KRAS
PIK3CA
BRAF
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 13 Mar 2014, 23:42:02 EST by Jiezhong Chen on behalf of School of Biomedical Sciences