Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy

Bouzigon, Emmanuelle, Forabosco, Paola, Koppelman, Gerard H., Cookson, William O. C. M., Dizier, Marie-Helene, Duffy, David L., Evans, David M., Ferreira, Manuel A. R., Kere, Juha, Laitinen, Tarja, Malerba, Giovanni, Meyers, Deborah A., Moffatt, Miriam, Martin, Nicholas G, Ng, Mandy Y., Pignatti, Pier Franco, Wjst, Mathias, Kauffmann, Francine, Demenais, Florence and Lewis, Cathryn M. (2010) Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. European Journal of Human Genetics, 18 6: 700-706. doi:10.1038/ejhg.2009.224


Author Bouzigon, Emmanuelle
Forabosco, Paola
Koppelman, Gerard H.
Cookson, William O. C. M.
Dizier, Marie-Helene
Duffy, David L.
Evans, David M.
Ferreira, Manuel A. R.
Kere, Juha
Laitinen, Tarja
Malerba, Giovanni
Meyers, Deborah A.
Moffatt, Miriam
Martin, Nicholas G
Ng, Mandy Y.
Pignatti, Pier Franco
Wjst, Mathias
Kauffmann, Francine
Demenais, Florence
Lewis, Cathryn M.
Title Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy
Journal name European Journal of Human Genetics   Check publisher's open access policy
ISSN 1018-4813
1476-5438
Publication date 2010
Sub-type Article (original research)
DOI 10.1038/ejhg.2009.224
Open Access Status
Volume 18
Issue 6
Start page 700
End page 706
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 2716 Genetics (clinical)
1311 Genetics
Abstract Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (≥3024 families with ≥10 027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21-p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3-q24 in all families for SPT and three other regions in European families (2q32-q34 for EOS, 5q23-q33 for SPTQ and 17q12-q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11-3q21, whereas between-study heterogeneity was detected for asthma in 2p22-p13 and 6p21, and for atopic asthma in 1q23-q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.
Keyword Asthma
Atopy
Linkage scan
Meta-analysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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