Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals

Heid, Iris M., Henneman, Peter, Hicks, Andrew, Coassin, Stefan, Winkler, Thomas, Aulchenko, Yurii S., Fuchsberger, Christian, Song, Kijoung, Hivert, Marie-France, Waterworth, Dawn M., Timpson, Nicholas J., Richards, J. Brent, Perry, John R. B., Tanaka, Toshiko, Amin, Najaf, Kollerits, Barbara, Pichler, Irene, Oostra, Ben A., Thorand, Barbara, Frants, Rune R., Illig, Thomas, Dupuis, Josée, Glaser, Beate, Spector, Tim, Guralnik, Jack, Egan, Josephine M., Florez, Jose C., Evans, David M., Soranzo, Nicole, Bandinelli, Stefania, Carlson, Olga D., Frayling, Timothy M., Burling, Keith, Smith, George Davey, Mooser, Vincent, Ferrucci, Luigi, Meigs, James B., Vollenweider, Peter, van Dijk, Ko Willems, Pramstaller, Peter, Kronenberg, Florian and van Duijn, Cornelia M. (2010) Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis, 208 2: 412-420. doi:10.1016/j.atherosclerosis.2009.11.035


Author Heid, Iris M.
Henneman, Peter
Hicks, Andrew
Coassin, Stefan
Winkler, Thomas
Aulchenko, Yurii S.
Fuchsberger, Christian
Song, Kijoung
Hivert, Marie-France
Waterworth, Dawn M.
Timpson, Nicholas J.
Richards, J. Brent
Perry, John R. B.
Tanaka, Toshiko
Amin, Najaf
Kollerits, Barbara
Pichler, Irene
Oostra, Ben A.
Thorand, Barbara
Frants, Rune R.
Illig, Thomas
Dupuis, Josée
Glaser, Beate
Spector, Tim
Guralnik, Jack
Egan, Josephine M.
Florez, Jose C.
Evans, David M.
Soranzo, Nicole
Bandinelli, Stefania
Carlson, Olga D.
Frayling, Timothy M.
Burling, Keith
Smith, George Davey
Mooser, Vincent
Ferrucci, Luigi
Meigs, James B.
Vollenweider, Peter
van Dijk, Ko Willems
Pramstaller, Peter
Kronenberg, Florian
van Duijn, Cornelia M.
Title Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2010
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2009.11.035
Open Access Status
Volume 208
Issue 2
Start page 412
End page 420
Total pages 9
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
Objective: Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women. We therefore aimed to investigate the genetics of plasma adiponectin in men and women.

Methods: We combined genome-wide association scans of three population-based studies including 4659 persons. For the replication stage in 13795 subjects, we selected the 20 top signals of the combined analysis, as well as the 10 top signals with p-values less than 1.0 × 10-4 for each the men- and the women-specific analyses. We further selected 73 SNPs that were consistently associated with metabolic syndrome parameters in previous genome-wide association studies to check for their association with plasma adiponectin.

Results: The ADIPOQ locus showed genome-wide significant p-values in the combined (p = 4.3 × 10-24) as well as in both women- and men-specific analyses (p = 8.7 × 10-17 and p = 2.5 × 10-11, respectively). None of the other 39 top signal SNPs showed evidence for association in the replication analysis. None of 73 SNPs from metabolic syndrome loci exhibited association with plasma adiponectin (p > 0.01).

Conclusions: We demonstrated the ADIPOQ gene as the only major gene for plasma adiponectin, which explains 6.7% of the phenotypic variance. We further found that neither this gene nor any of the metabolic syndrome loci explained the sex differences observed for plasma adiponectin. Larger studies are needed to identify more moderate genetic determinants of plasma adiponectin. 
Keyword Adiponectin
Cardiovascular disease
Genome-wide association study
Metabolic syndrome
Polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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