Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott, Robert A., Lagou, Vasiliki, Welch, Ryan P., Wheeler, Eleanor, Montasser, May E., Luan, Jian’an, Mägi, Reedik, Strawbridge, Rona J., Rehnberg, Emil, Gustafsson, Stefan, Kanoni, Stavroula, Rasmussen-Torvik, Laura J., Yengo, Loïc, Lecoeur, Cecile, Shungin, Dmitry, Sanna, Serena, Sidore, Carlo, Johnson, Paul C. D., Jukema, J. Wouter, Johnson, Toby, Mahajan, Anubha, Verweij, Niek, Thorleifsson, Gudmar, Hottenga, Jouke-Jan, Shah, Sonia, Smith, Albert V., Sennblad, Bengt, Gieger, Christian, Salo, Perttu, Perola, Markus, Timpson, Nicholas J., Evans, David M., St Pourcain, Beate, Wu, Ying, Andrews, Jeanette S., Hui, Jennie, Bielak, Lawrence F., Zhao, Wei, Horikoshi, Momoko, Navarro, Pau, Isaacs, Aaron, O'Connell, Jeffrey R., Stirrups, Kathleen, Vitart, Veronique, Hayward, Caroline, Esko, Tõnu, Mihailov, Evelin, Fraser, Ross M., Fall, Tove, Voight, Benjamin F., Raychaudhuri, Soumya, Chen, Han, Lindgren, Cecilia M., Morris, Andrew P., Rayner, Nigel W., Robertson, Neil, Rybin, Denis, Liu, Ching-Ti, Beckmann, Jacques S., Willems, Sara M., Chines, Peter S., Jackson, Anne U., Kang, Hyun Min., Stringham, Heather M., Song, Kijoung, Tanaka, Toshiko, Peden, John F., Goel, Anuj, Hicks, Andrew A., An, Ping, Müller-Nurasyid, Martina, Franco-Cereceda, Anders, Folkersen, Lasse, Marullo, Letizia, Jansen, Hanneke, Oldehinkel, Albertine J., Bruinenberg, Marcel, Pankow, James S., North, Kari E., Forouhi, Nita G., Loos, Ruth J. F., Edkins, Sarah, Varga, Tibor V., Hallmans, Göran, Oksa, Heikki, Antonella, Mulas, Nagaraja, Ramaiah, Trompet, Stella, Ford, Ian, Bakker, Stephan J. L., Kong, Augustine, Kumari, Meena, Gigante, Bruna, Herder, Christian, Munroe, Patricia B., Caulfield, Mark, Antti, Jula, Mangino, Massimo, Small, Kerrin, Miljkovic, Iva, Liu, Yongmei, Atalay, Mustafa, Kiess, Wieland, James, Alan L., Rivadeneira, Fernando, Uitterlinden, Andre G., Palmer, Colin N. A., Doney, Alex S. F., Willemsen, Gonneke, Smit, Johannes H., Campbell, Susan, Polasek, Ozren, Bonnycastle, Lori L., Hercberg, Serge, Dimitriou, Maria, Bolton, Jennifer L., Fowkes, Gerard R., Kovacs, Peter, Lindström, Jaana, Zemunik, Tatijana, Bandinelli, Stefania, Wild, Sarah H., Basart, Hanneke V., Rathmann, Wolfgang, Grallert, Harald, Maerz, Winfried, Kleber, Marcus E., Boehm, Bernhard O., Peters, Annette, Pramstaller, Peter P., Province, Michael A., Borecki, Ingrid B., Hastie, Nicholas D., Rudan, Igor, Campbell, Harry, Watkins, Hugh, Farrall, Martin, Stumvoll, Michael, Ferrucci, Luigi, Waterworth, Dawn M., Bergman, Richard N., Collins, Francis S., Tuomilehto, Jaakko, Watanabe, Richard M., de Geus, Eco J. C., Penninx, Brenda W., Hofman, Albert, Oostra, Ben A., Psaty, Bruce M., Vollenweider, Peter, Wilson, James F., Wright, Alan F., Hovingh, G. Kees, Metspalu, Andres, Uusitupa, Matti, Magnusson, Patrik K. E., Kyvik, Kirsten O., Kaprio, Jaakko, Price, Jackie F., Dedoussis, George V., Deloukas, Panos, Meneton, Pierre, Lind, Lars, Boehnke, Michael, Shuldiner, Alan R., van Duijn, Cornelia M., Morris, Andrew D., Toenjes, Anke, Peyser, Patricia A., Beilby, John P., Körner, Antje, Kuusisto, Johanna, Laakso, Markku, Bornstein, Stefan R., Schwarz, Peter E. H., Lakka, Timo A., Rauramaa, Rainer, Adair, Linda S., Smith, George Davey, Spector, Tim D., Illig, Thomas, de Faire, Ulf, Hamsten, Anders, Gudnason, Vilmundur, Kivimaki, Mika, Hingorani, Aroon, Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Boomsma, Dorret I., Stefansson, Kari, van der Harst, Pim, Dupuis, Josée, Pedersen, Nancy L., Sattar, Naveed, Harris, Tamara B., Cucca, Francesco, Ripatti, Samuli, Salomaa, Veikko, Mohlke, Karen L., Balkau, Beverley, Froguel, Philippe, Pouta, Anneli, Jarvelin, Marjo-Riitta, Wareham, Nicholas J., Bouatia-Naji, Nabila, McCarthy, Mark I., Franks, Paul W., Meigs, James B., Teslovich, Tanya M., Florez, Jose C., Langenberg, Claudia, Ingelsson, Erik, Prokopenko, Inga and Barroso, Inês (2012) Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 9: 991-1005. doi:10.1038/ng.2385


Author Scott, Robert A.
Lagou, Vasiliki
Welch, Ryan P.
Wheeler, Eleanor
Montasser, May E.
Luan, Jian’an
Mägi, Reedik
Strawbridge, Rona J.
Rehnberg, Emil
Gustafsson, Stefan
Kanoni, Stavroula
Rasmussen-Torvik, Laura J.
Yengo, Loïc
Lecoeur, Cecile
Shungin, Dmitry
Sanna, Serena
Sidore, Carlo
Johnson, Paul C. D.
Jukema, J. Wouter
Johnson, Toby
Mahajan, Anubha
Verweij, Niek
Thorleifsson, Gudmar
Hottenga, Jouke-Jan
Shah, Sonia
Smith, Albert V.
Sennblad, Bengt
Gieger, Christian
Salo, Perttu
Perola, Markus
Timpson, Nicholas J.
Evans, David M.
St Pourcain, Beate
Wu, Ying
Andrews, Jeanette S.
Hui, Jennie
Bielak, Lawrence F.
Zhao, Wei
Horikoshi, Momoko
Navarro, Pau
Isaacs, Aaron
O'Connell, Jeffrey R.
Stirrups, Kathleen
Vitart, Veronique
Hayward, Caroline
Esko, Tõnu
Mihailov, Evelin
Fraser, Ross M.
Fall, Tove
Voight, Benjamin F.
Raychaudhuri, Soumya
Chen, Han
Lindgren, Cecilia M.
Morris, Andrew P.
Rayner, Nigel W.
Robertson, Neil
Rybin, Denis
Liu, Ching-Ti
Beckmann, Jacques S.
Willems, Sara M.
Chines, Peter S.
Jackson, Anne U.
Kang, Hyun Min.
Stringham, Heather M.
Song, Kijoung
Tanaka, Toshiko
Peden, John F.
Goel, Anuj
Hicks, Andrew A.
An, Ping
Müller-Nurasyid, Martina
Franco-Cereceda, Anders
Folkersen, Lasse
Marullo, Letizia
Jansen, Hanneke
Oldehinkel, Albertine J.
Bruinenberg, Marcel
Pankow, James S.
North, Kari E.
Forouhi, Nita G.
Loos, Ruth J. F.
Edkins, Sarah
Varga, Tibor V.
Hallmans, Göran
Oksa, Heikki
Antonella, Mulas
Nagaraja, Ramaiah
Trompet, Stella
Ford, Ian
Bakker, Stephan J. L.
Kong, Augustine
Kumari, Meena
Gigante, Bruna
Herder, Christian
Munroe, Patricia B.
Caulfield, Mark
Antti, Jula
Mangino, Massimo
Small, Kerrin
Miljkovic, Iva
Liu, Yongmei
Atalay, Mustafa
Kiess, Wieland
James, Alan L.
Rivadeneira, Fernando
Uitterlinden, Andre G.
Palmer, Colin N. A.
Doney, Alex S. F.
Willemsen, Gonneke
Smit, Johannes H.
Campbell, Susan
Polasek, Ozren
Bonnycastle, Lori L.
Hercberg, Serge
Dimitriou, Maria
Bolton, Jennifer L.
Fowkes, Gerard R.
Kovacs, Peter
Lindström, Jaana
Zemunik, Tatijana
Bandinelli, Stefania
Wild, Sarah H.
Basart, Hanneke V.
Rathmann, Wolfgang
Grallert, Harald
Maerz, Winfried
Kleber, Marcus E.
Boehm, Bernhard O.
Peters, Annette
Pramstaller, Peter P.
Province, Michael A.
Borecki, Ingrid B.
Hastie, Nicholas D.
Rudan, Igor
Campbell, Harry
Watkins, Hugh
Farrall, Martin
Stumvoll, Michael
Ferrucci, Luigi
Waterworth, Dawn M.
Bergman, Richard N.
Collins, Francis S.
Tuomilehto, Jaakko
Watanabe, Richard M.
de Geus, Eco J. C.
Penninx, Brenda W.
Hofman, Albert
Oostra, Ben A.
Psaty, Bruce M.
Vollenweider, Peter
Wilson, James F.
Wright, Alan F.
Hovingh, G. Kees
Metspalu, Andres
Uusitupa, Matti
Magnusson, Patrik K. E.
Kyvik, Kirsten O.
Kaprio, Jaakko
Price, Jackie F.
Dedoussis, George V.
Deloukas, Panos
Meneton, Pierre
Lind, Lars
Boehnke, Michael
Shuldiner, Alan R.
van Duijn, Cornelia M.
Morris, Andrew D.
Toenjes, Anke
Peyser, Patricia A.
Beilby, John P.
Körner, Antje
Kuusisto, Johanna
Laakso, Markku
Bornstein, Stefan R.
Schwarz, Peter E. H.
Lakka, Timo A.
Rauramaa, Rainer
Adair, Linda S.
Smith, George Davey
Spector, Tim D.
Illig, Thomas
de Faire, Ulf
Hamsten, Anders
Gudnason, Vilmundur
Kivimaki, Mika
Hingorani, Aroon
Keinanen-Kiukaanniemi, Sirkka M.
Saaristo, Timo E.
Boomsma, Dorret I.
Stefansson, Kari
van der Harst, Pim
Dupuis, Josée
Pedersen, Nancy L.
Sattar, Naveed
Harris, Tamara B.
Cucca, Francesco
Ripatti, Samuli
Salomaa, Veikko
Mohlke, Karen L.
Balkau, Beverley
Froguel, Philippe
Pouta, Anneli
Jarvelin, Marjo-Riitta
Wareham, Nicholas J.
Bouatia-Naji, Nabila
McCarthy, Mark I.
Franks, Paul W.
Meigs, James B.
Teslovich, Tanya M.
Florez, Jose C.
Langenberg, Claudia
Ingelsson, Erik
Prokopenko, Inga
Barroso, Inês
Title Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2012
Sub-type Article (original research)
DOI 10.1038/ng.2385
Open Access Status
Volume 44
Issue 9
Start page 991
End page 1005
Total pages 15
Place of publication New York, NY, United States
Publisher Nature Publishing
Language eng
Subject 1311 Genetics
Abstract Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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