Unraveling macrophage contributions to bone repair

Wu, Andy C., Raggatt, Liza J., Alexander, Kylie A. and Pettit, Allison R. (2013) Unraveling macrophage contributions to bone repair. BoneKEy Reports, 2 373: 1-1. doi:10.1038/bonekey.2013.107

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Wu, Andy C.
Raggatt, Liza J.
Alexander, Kylie A.
Pettit, Allison R.
Title Unraveling macrophage contributions to bone repair
Journal name BoneKEy Reports   Check publisher's open access policy
ISSN 2047-6396
Publication date 2013-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/bonekey.2013.107
Volume 2
Issue 373
Start page 1
End page 1
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Formatted abstract
Macrophages have reemerged to prominence with widened understanding of their pleiotropic contributions to many biologies and pathologies. This includes clear advances in revealing their importance in wound healing. Here we have focused on the current state of knowledge with respect to bone repair, which has received relatively little scientific attention compared with its soft-tissue counterparts. Our detailed characterization of resident tissue macrophages residing in bone-lining tissues (osteomacs), including their pro-anabolic function, exposed a more prominent role for these cells in bone biology than previously anticipated. Recent studies have confirmed the importance of macrophages in early inflammatory processes that establish the healing cascade after bone fracture. Emerging data support that macrophage influence extends into both anabolic and catabolic phases of repair, suggesting that these cells have prolonged and diverse functions during fracture healing. More research is needed to clarify macrophage phase-specific contributions, temporospatial subpopulation variance and macrophage specific-molecular mediators. There is also clear motivation for determining whether macrophage alterations underlie compromised fracture healing. Overall, there is strong justification to pursue strategies targeting macrophages and/or their products for improving normal bone healing and overcoming failed repair.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 12 Mar 2014, 12:18:28 EST by Roheen Gill on behalf of UQ Centre for Clinical Research