Statins: protectors or pretenders in prostate cancer?

Moon, Hyeongsun, Hill, Michelle M., Roberts, Matthew J., Gardiner, Robert A. and Brown, Andrew J. (2014) Statins: protectors or pretenders in prostate cancer?. Trends in Endocrinology and Metabolism, 25 4: 188-196. doi:10.1016/j.tem.2013.12.007


Author Moon, Hyeongsun
Hill, Michelle M.
Roberts, Matthew J.
Gardiner, Robert A.
Brown, Andrew J.
Title Statins: protectors or pretenders in prostate cancer?
Journal name Trends in Endocrinology and Metabolism   Check publisher's open access policy
ISSN 1043-2760
1879-3061
Publication date 2014-04
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tem.2013.12.007
Open Access Status
Volume 25
Issue 4
Start page 188
End page 196
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Ltd. * Trends Journals
Collection year 2014
Language eng
Abstract The role of statin therapy in prostate cancer (PCa) prevention and treatment is plagued by controversy. This critical review of published clinical series reveals several caveats in earlier studies, which reported no benefit. Recent studies that adjust for confounding factors have demonstrated statin therapy to be associated with PCa prevention and favorable clinical outcomes. Developed as inhibitors of cholesterol synthesis, the expected mechanism of statin action is systemic cholesterol reduction. By lowering circulating cholesterol, statins indirectly reduce cellular cholesterol levels in multiple cell types, impacting on membrane microdomains and steroidogenesis. Although non-cholesterol mechanisms of statin action have been proposed, they are limited by the uncertainties surrounding in vivo tissue statin concentrations.
Keyword Androgen synthesis
Cholesterol
HMG-CoA reductase
Prenylation
Prostate cancer
Statin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Wed, 12 Mar 2014, 12:00:21 EST by Roheen Gill on behalf of UQ Centre for Clinical Research