Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze

Hort, J., Andel, R., Mokrisova, I., Gazova, I., Amlerova, J., Valis, M., Coulson, E. J., Harrison, J., Windisch, M. and Laczo, J. (2014) Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze. Neurodegenerative Diseases, 13 2-3: 192-196. doi:10.1159/000355517


Author Hort, J.
Andel, R.
Mokrisova, I.
Gazova, I.
Amlerova, J.
Valis, M.
Coulson, E. J.
Harrison, J.
Windisch, M.
Laczo, J.
Title Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze
Journal name Neurodegenerative Diseases   Check publisher's open access policy
ISSN 1660-2854
1660-2862
Publication date 2014-01
Year available 2013
Sub-type Article (original research)
DOI 10.1159/000355517
Open Access Status
Volume 13
Issue 2-3
Start page 192
End page 196
Total pages 5
Place of publication Basel, Switzerland
Publisher S. Karger AG
Collection year 2014
Language eng
Formatted abstract
Background: Drug development for Alzheimer disease (AD) is challenged by the success in animal models tested in the Morris water maze (MWM) and the subsequent failures to meet primary outcome measures in phase II or III clinical trials in patients. The human variant of MWM (hMWM) enables us to examine allocentric and egocentric navigation as in the MWM. Objective: It was the aim of this study to examine the utility of a computerized hMWM to assess the effects of donepezil in mild AD. Methods: Donepezil 5 mg/day was started after initial hMWM testing in the treated group (n = 12), and after 28 days, the dose was increased to 10 mg/day. The performance after 3 months was compared to that of a non-treated group (n = 12). Results: Donepezil stabilized or improved the spatial navigation performance after 3 months, especially in the allocentric delayed recall subtask (p = 0.014). Conclusions: The computerized hMWM has the potential to measure the effects of donepezil in mild AD. It is a sensitive cognitive outcome measure in AD clinical trials.
Keyword Alzheimer disease
Donepezil
Human analog of the Morris water maze
Morris water maze
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 30 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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