Efficacy and safety of topical trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial

Maenthaisong, Ratree, Chaiyakunapruk, Nathorn, Tiyaboonchai, Waree, Tawatsin, Apiwat, Rojanawiwat, Archawin and Thavara, Usavadee (2014) Efficacy and safety of topical trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial. Complementary Therapies in Medicine, 22 1: 34-39. doi:10.1016/j.ctim.2013.08.014


Author Maenthaisong, Ratree
Chaiyakunapruk, Nathorn
Tiyaboonchai, Waree
Tawatsin, Apiwat
Rojanawiwat, Archawin
Thavara, Usavadee
Title Efficacy and safety of topical trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial
Journal name Complementary Therapies in Medicine   Check publisher's open access policy
ISSN 0965-2299
1873-6963
Publication date 2014-02
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.ctim.2013.08.014
Open Access Status
Volume 22
Issue 1
Start page 34
End page 39
Total pages 6
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Collection year 2014
Language eng
Formatted abstract
Introduction
Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R. Although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. Therefore, we performed a double-blind, within person-randomized controlled study of 30 healthy volunteers to determine efficacy and safety of topical Trikatu on mosquito bite reactions.

Methods
All subjects were bitten by Aedes aegypti laboratory mosquitoes on their forearms and they were randomly assigned arms to apply either Trikatu or reference product on the mosquito bite papule. The main outcome was the difference of papule size reduction at 30 min, measured by a caliper, between the Trikatu and reference arms. Pruritis, redness, pain, and patient satisfaction were assessed at 15, 30, 60, 180, and 360 min as secondary outcomes.

Results
There were no significant differences between treatment and reference arms on any outcome at any time of measurement.

Conclusion

Trikatu did not show additional effects for relieving mosquito bite reaction as compared with the reference product containing camphor, menthol, and eucalyptus. For further study, it is very important to consider a proper selection of subjects, comparator product, and concentration of extract when Trikatu preparation is investigated.
Keyword Eucalyptus oil
Mosquito bite
Mosquito bite symptoms
Papule size reduction
Trikatu preparation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
 
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