The Schistosoma japonicum self-cure phenomenon in water buffaloes: Potential impact on the control and elimination of schistosomiasis in China

Li, Yue-Sheng, McManus, Donald P., Lin, Dan-Dan, Williams, Gail M., Harn, Donald A., Ross, Allen G., Feng, Zheng and Gray, Darren J. (2014) The Schistosoma japonicum self-cure phenomenon in water buffaloes: Potential impact on the control and elimination of schistosomiasis in China. International Journal for Parasitology, 44 3-4: 167-171. doi:10.1016/j.ijpara.2013.10.007


Author Li, Yue-Sheng
McManus, Donald P.
Lin, Dan-Dan
Williams, Gail M.
Harn, Donald A.
Ross, Allen G.
Feng, Zheng
Gray, Darren J.
Title The Schistosoma japonicum self-cure phenomenon in water buffaloes: Potential impact on the control and elimination of schistosomiasis in China
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
1879-0135
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.ijpara.2013.10.007
Open Access Status DOI
Volume 44
Issue 3-4
Start page 167
End page 171
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier Ltd
Collection year 2015
Language eng
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Schistosomiasis japonica, caused by Schistosoma japonicum, is an important zoonotic disease in China, the Philippines and small pockets of Indonesia. In addition to infecting people, S. japonicum can infect over 40 species of wild and domestic animals which have varying impacts on human infection. It is now generally accepted that bovines, particularly water buffaloes, are the major reservoir for human infection in China as they are naturally infected with schistosomes and deposit more eggs into the environment than humans or any other animal host. This complicates control efforts and the economic burden associated with schistosomiasis morbidity and mortality has taken its toll on both human and livestock populations. Over the last 50. years, the schistosomiasis control program in China has made great strides in reducing prevalence and morbidity, and the Chinese authorities now aim to eliminate the disease nationwide in the next decade. Current Chinese control strategies place particular importance on interventions targeting bovines including: praziquantel treatment, barrier farming to prevent grazing in transmission areas, their replacement with mechanized tractors and possible bovine vaccination. A number of studies have shown that in the period following S. japonicum infection, the worm burden drops sharply in water buffaloes and some other animal hosts such as pigs. This is due to a self-cure phenomenon whereby there is parasite clearance by both immune and non-immune factors. Here we review studies investigating the self-cure effect, paying particular attention to S. japonicum infection in water buffaloes, and discuss its potential impact on the future schistosomiasis control and elimination efforts in China. Further understanding of the mechanism of self-cure in water buffaloes could be important for future schistosome vaccine design and delivery.
Keyword China
Infection
Schistosoma japonicum
Schistosomiasis
Self cure phenomenon
Water buffaloes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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