Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

Chuah, Candy, Jones, Malcolm K., Burke, Melissa L., McManus, Donald P. and Gobert, Geoffrey N. (2014) Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology. Trends in Parasitology, 30 3: 141-150. doi:10.1016/j.pt.2013.12.009


Author Chuah, Candy
Jones, Malcolm K.
Burke, Melissa L.
McManus, Donald P.
Gobert, Geoffrey N.
Title Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology
Journal name Trends in Parasitology   Check publisher's open access policy
ISSN 1471-4922
1471-5007
Publication date 2014-01-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pt.2013.12.009
Open Access Status DOI
Volume 30
Issue 3
Start page 141
End page 150
Total pages 10
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Ltd
Collection year 2015
Language eng
Subject 2725 Infectious Diseases
2405 Parasitology
Abstract In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the host liver, evoking an interleukin 4 (IL-4)- and IL-13-mediated dominant CD4+ Th2 immune response. This response leads to the development of granulomas and fibrosis, with eosinophils, neutrophils, macrophages, hepatic stellate cells, and lymphocytes all identified as major cellular contributors to these events. This review outlines the cellular and molecular mechanisms of hepatic schistosomiasis, with an emphasis on the major cellular components and their release of chemokines. The differences between Schistosoma mansoni- and Schistosoma japonicum-induced hepatic granuloma are also discussed. This comprehensive overview of the processes associated with hepatic schistosomiasis may provide new insights into improved treatment for both schistosomiasis and other granulofibrotic diseases.
Keyword Chemokine
Granuloma
Immunopathology
Schistosomiasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 36 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 11 Mar 2014, 10:30:23 EST by System User on behalf of School of Veterinary Science