Extrasensory perception: odorant and taste receptors beyond the nose and mouth

Foster, Simon R., Roura, Eugeni and Thomas, Walter G. (2014) Extrasensory perception: odorant and taste receptors beyond the nose and mouth. Pharmacology and Therapeutics, 142 1: 41-61. doi:10.1016/j.pharmthera.2013.11.004

Author Foster, Simon R.
Roura, Eugeni
Thomas, Walter G.
Title Extrasensory perception: odorant and taste receptors beyond the nose and mouth
Journal name Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0163-7258
Publication date 2014
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.pharmthera.2013.11.004
Open Access Status
Volume 142
Issue 1
Start page 41
End page 61
Total pages 21
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2014
Language eng
Abstract G protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors and are prime therapeutic targets. The odorant and taste receptors account for over half of the GPCR repertoire, yet they are generally excluded from large-scale, drug candidate analyses. Accumulating molecular evidence indicates that the odorant and taste receptors are widely expressed throughout the body and functional beyond the oronasal cavity - with roles including nutrient sensing, autophagy, muscle regeneration, regulation of gut motility, protective airway reflexes, bronchodilation, and respiratory disease. Given this expanding array of actions, the restricted perception of these GPCRs as mere mediators of smell and taste is outdated. Moreover, delineation of the precise actions of odorant and taste GPCRs continues to be hampered by the relative paucity of selective and specific experimental tools, as well as the lack of defined receptor pharmacology. In this review, we summarize the evidence for expression and function of odorant and taste receptors in tissues beyond the nose and mouth, and we highlight their broad potential in physiology and pathophysiology.
Keyword G protein-coupled receptor
Odorant receptor
Taste receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
Centre for Nutrition and Food Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
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