Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria

Kim, Kyungchul, Waterer, Grant, Thomson, Rachel, Yang, Ian A., Nashi, Najla, Tan, Dino B. A. and Price, Patricia (2014) Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria. Cytokine, 66 2: 160-163. doi:10.1016/j.cyto.2014.01.005


Author Kim, Kyungchul
Waterer, Grant
Thomson, Rachel
Yang, Ian A.
Nashi, Najla
Tan, Dino B. A.
Price, Patricia
Title Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria
Journal name Cytokine   Check publisher's open access policy
ISSN 1043-4666
1096-0023
Publication date 2014-04
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.cyto.2014.01.005
Open Access Status
Volume 66
Issue 2
Start page 160
End page 163
Total pages 4
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2015
Language eng
Subject 2403 Immunology
2723 Immunology and Allergy
2720 Hematology
1303 Specialist Studies in Education
1312 Molecular Biology
Formatted abstract
Pulmonary disease due to non-tuberculous mycobacteria (NTM) is caused by several species (particularly Mycobacterium avium, Mycobacterium intracellulare) that are abundant in the environment. Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro production of IFN-γ is not deficient in adult patients with pulmonary NTM disease. Antibodies reactive with IFN-γ have been described in patients with disseminated NTM disease, but it is not clear whether they are common in pulmonary disease. Here we show that patients with pulmonary NTM have a higher level of anti-IFN-γ and anti-GM-CSF antibodies than healthy controls, although some controls also have high levels. Levels of anti-IFN-γ antibodies did not correlate with levels of total immunoglobulin. Longitudinal studies are required to determine whether anti-cytokine autoantibodies are consequence rather than a cause of pulmonary NTM disease.
Keyword Autoantibody
Cytokine
Interferon-γ
Non-tuberculous mycobacteria
Pulmonary disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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