Do transformation products contribute to mixture toxicity?

Cordua, Birgitte, Tang, Janet Yat-Man, Allard, Sebastien, Busetti, Francesco, Cedergreen, Nina, Charrois, Jeffrey and Escher, Beate (2013). Do transformation products contribute to mixture toxicity?. In: 3rd SETAC Australasia Conference: Melbourne 2013. Conference Handbook. 3rd SETAC Australasia Conference: Melbourne 2013, Melbourne Australia, (). 1-3 October, 2013.

Author Cordua, Birgitte
Tang, Janet Yat-Man
Allard, Sebastien
Busetti, Francesco
Cedergreen, Nina
Charrois, Jeffrey
Escher, Beate
Title of paper Do transformation products contribute to mixture toxicity?
Conference name 3rd SETAC Australasia Conference: Melbourne 2013
Conference location Melbourne Australia
Conference dates 1-3 October, 2013
Convener Society of Environmental Toxicology and Chemistry (SETAC)
Proceedings title 3rd SETAC Australasia Conference: Melbourne 2013. Conference Handbook
Place of Publication Melbourne, VIC, Australia
Publisher SETAC Australasia
Publication Year 2013
Sub-type Published abstract
Language eng
Formatted Abstract/Summary
Transformation products (TPs) and oxidation byproducts have been found in water that has undergone oxidative treatment, however, only a few of them are currently regulated around the world. The traditional process of identifying, isolating and quantifying hazardous transformation products and oxidation byproducts is costly and time consuming; therefore, we propose to develop a tiered approach for screening organic micropollutants for their potential to form toxicologically relevant transformation products that combines in parallel bioanalytical assessment and identification and quantification of the formed transformation products. Laboratory experiments were conducted with a range of compounds, some of which were previously detected at an Australian Wastewater Treatment Plant, whose effluent is fed into an Advanced Water Recycling Plant (AWRP). Selected chemicals (found only before RO) were pesticides atrazine, hexazinone, haloxyfop, endocrine disrupting compound bisphenol A, X-ray contrast media iopromide, pharmaceuticals carbamazepine, diclofenac, and antibiotic sulfamethoxazole. Bench-scale experiments were first performed in post-RO water collected from the AWRP for accurate control of the oxidation process as well as monitoring of the degradation kinetics. The transformation processes was tested with different ozone doses (0 - 150 µM). The degradation kinetics of the parent compound were measured using LC-MS/MS. The bioanalytical equivalent concentrations were compared with the parent compound concentrations and only if these did not correlate linearly with the decrease of the parent compound concentration, it would be an indication that more or equally potent TPs were formed during the oxidation process. Those samples will then go into a higher tier assessment where the formed TPs will be identified using LC-IT/HRMS (Orbitrap). So far, no experiment showed the formation of toxic TPs. Additional oxidation experiments involving ozone, hydroxyl radical and direct UV photolysis will be conducted to determine the best option to remove previously identified toxic TPs in case any will be found.
Q-Index Code EX
Q-Index Status Provisional Code

Document type: Conference Paper
Collection: National Research Centre for Environmental Toxicology Publications
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Created: Tue, 04 Mar 2014, 17:11:02 EST by Ms Janet Tang on behalf of National Res Centre For Environmental Toxicology