Illicit drug use in late pregnancy associated with stillbirth and eclampsia

Scott, Katherine, Fagermo, Narelle, Callaway, Leonie and Lust, Karin (2010) Illicit drug use in late pregnancy associated with stillbirth and eclampsia. Obstetric Medicine, 3 3: 113-114. doi:10.1258/om.2010.090061


Author Scott, Katherine
Fagermo, Narelle
Callaway, Leonie
Lust, Karin
Title Illicit drug use in late pregnancy associated with stillbirth and eclampsia
Journal name Obstetric Medicine   Check publisher's open access policy
ISSN 1753-495X
1753-4968
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1258/om.2010.090061
Open Access Status
Volume 3
Issue 3
Start page 113
End page 114
Total pages 2
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Formatted abstract
We present the case of a 20-year-old student with an undiagnosed pregnancy who had taken ecstasy and LSD (lysergic acid diethylamide). Twenty-four hours later she delivered a stillborn term infant, and subsequently developed eclampsia with seizures, hypertension and proteinuria. Illicit drug use is relatively common in women of child-bearing age in Australia, and is a risk factor for adverse obstetric outcomes. Ecstasy (MDMA [3,4-methylenedioxymethamphetamine]) is a sympathomimetic amine, similar to amphetamine in its cardiovascular effects. LSD is a hallucinogen with complex pharmacology and has potential for significant compromise of placental blood flow. We propose that the combined vasoconstrictive effects of MDMA and LSD caused placental ischaemia, contributing to the fetal death and precipitating a cascade of endothelial dysfunction which resulted in an eclamptic syndrome.
Keyword Drugs (abuse)
Illicit drugs
Eclampsia
Pregnancy
LSD
MDMA
Placenta
Preeclampsia
Illicit drug use
Stillbirth
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 04 Mar 2014, 14:28:11 EST by Karin Lust on behalf of Medicine - Royal Brisbane and Women's Hospital