Investigation of compounds with cytotoxic activity in Carica papaya leaves

Nguyen, Thao, Parat, Marie-Odile, Hodson, Mark P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2014). Investigation of compounds with cytotoxic activity in Carica papaya leaves. In: 6th International Conference on Drug Discovery & Therapy: Abstracts. ICDDT 2014: 6th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, (126-126). February 2014.

Author Nguyen, Thao
Parat, Marie-Odile
Hodson, Mark P.
Shaw, P. Nicholas
Hewavitharana, Amitha K.
Title of paper Investigation of compounds with cytotoxic activity in Carica papaya leaves
Formatted title
Investigation of compounds with cytotoxic activity in Carica papaya leaves
Conference name ICDDT 2014: 6th International Conference on Drug Discovery and Therapy
Conference location Dubai, United Arab Emirates
Conference dates February 2014
Proceedings title 6th International Conference on Drug Discovery & Therapy: Abstracts
Place of Publication Saif Zone, Sharjah, UAE
Publication Year 2014
Sub-type Published abstract
Open Access Status
Start page 126
End page 126
Total pages 1
Language eng
Formatted Abstract/Summary
In traditional medicine, various parts of Carica papaya such as leaves, bark, roots, latex, fruits, flowers and seeds have been used for a wide range of therapeutic applications. Carica papaya leaves have been reported to possess healing capabilities against cancer in an increasing number of anecdotal reports. Therefore, we investigated the cytotoxic activities as well as the chromatographic profiles of different extracts from Carica papaya leaves in order to detect bioactive compounds with anticancer activities. Assessment of cell death using a validated MTT assay indicated that all studied extracts affected the viability of human oral squamous cell carcinoma (SCC25) cells. Ultra High Performance Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry was used to acquire chromatographic profiles and mass spectra with high mass accuracy and sensitivity. A list of the features found to be similar in all the extracts was explored to generate putative molecular formulae of potential therapeutic compounds. Further work, including confirmation viaauthentic standard comparison and tandem mass spectrometry, as well as cytotoxicity studies of pure compounds will confirm the identity and the therapeutic activities of the bioactive compounds in Carica papaya leaves.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Pharmacy Publications
 
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Created: Tue, 04 Mar 2014, 09:47:43 EST by Amitha Hewavitharana on behalf of School of Pharmacy