Can Terahertz time-domain spectroscopy detect an extended hydration layer around peptides?

Ding, T., Middelberg, A.P.J., Bye, J.M. and Falconer, R.J. (2013). Can Terahertz time-domain spectroscopy detect an extended hydration layer around peptides?. In: IRMMW-THz : Mainz 2013 : 2013 38th International Conference on Infrared, Millimeter, and Terahertz Waves : (IRMMW-THz). 38th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2013, Mainz, Germany, (). 1 - 6 September 2013. doi:10.1109/IRMMW-THz.2013.6665563

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Author Ding, T.
Middelberg, A.P.J.
Bye, J.M.
Falconer, R.J.
Title of paper Can Terahertz time-domain spectroscopy detect an extended hydration layer around peptides?
Conference name 38th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2013
Conference location Mainz, Germany
Conference dates 1 - 6 September 2013
Proceedings title IRMMW-THz : Mainz 2013 : 2013 38th International Conference on Infrared, Millimeter, and Terahertz Waves : (IRMMW-THz)
Journal name International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Place of Publication Piscataway NJ, United States
Publisher I E E E
Publication Year 2013
Year available 2013
Sub-type Fully published paper
DOI 10.1109/IRMMW-THz.2013.6665563
Open Access Status
ISBN 9781467347174
1467347175
ISSN 2162-2027
Total pages 2
Collection year 2014
Language eng
Abstract/Summary A peptide was added to a KF solution and the absorbance measured by Terahertz time-domain spectroscopy (THz-TDS). The absorbance dropped then plateaued at ∼25 mM. This is consistent with a hydration layer around 11-17 Å thick with lower absorbance than bulk water. Terahertz spectroscopy using synchrotron light performed on a solution containing the protein bovine serum albumin (BSA) confirmed the rise in absorbance observed using p-germanium spectroscopy and the plateauing observed by THz-TDS in aqueous peptide samples. Using the inflection in the decline of the absorbance, the thickness of the hydration layer around BSA can be estimated at 15A thick.
Subjects 2102 Curatorial and Related Studies
2208 Electrical and Electronic Engineering
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ

 
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