Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age

Borradale, D., Isenring, E., Hacker, E. and Kimlin, M. G. (2014) Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age. Journal of Photochemistry and Photobiology B: Biology, 131 90-95. doi:10.1016/j.jphotobiol.2014.01.002


Author Borradale, D.
Isenring, E.
Hacker, E.
Kimlin, M. G.
Title Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age
Journal name Journal of Photochemistry and Photobiology B: Biology   Check publisher's open access policy
ISSN 1011-1344
1873-2682
Publication date 2014-02-05
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jphotobiol.2014.01.002
Open Access Status
Volume 131
Start page 90
End page 95
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
In vitro studies indicate that folate in collected human blood is vulnerable to degradation after exposure to ultraviolet (UV) radiation. This has raised concerns about folate depletion in individuals with high sun exposure. Here, we investigate the association between personal solar UV radiation exposure and serum folate concentration, using a three-week prospective study that was undertaken in females aged 18–47 years in Brisbane, Australia (153 E, 27 S). Following two weeks of supplementation with 500 μg of folic acid daily, the change in serum folate status was assessed over a 7-day period of measured personal sun exposure. Compared to participants with personal UV exposures of <200 Joules per day, participants with personal UV exposures of 200–599 and >600 Joules per day had significantly higher depletion of serum folate (p = 0.015). Multivariable analysis revealed personal UV exposure as the strongest predictor accounting for 20% of the overall change in serum folate (Standardised B = −0.49; t = −3.75; p = <0.01). These data show that increasing solar UV radiation exposures reduces the effectiveness of folic acid supplementation. The consequences of this association may be most pronounced for vulnerable individuals, such as women who are pregnant or of childbearing age with high sun exposures.
Keyword Population study
Folate
Folic acid
Solar ultraviolet radiation
Photodegradation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Human Movement and Nutrition Sciences Publications
 
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