Vasomotor menopausal symptoms are not associated with incidence of breast cancer in a population-based cohort of mid-aged women

Van Den Berg, M. Johanneke, Mishra, Gita D., Van Der Schouw, Yvonne T. and Herber-Gast, Gerrie-Cor M. (2014) Vasomotor menopausal symptoms are not associated with incidence of breast cancer in a population-based cohort of mid-aged women. European Journal of Cancer, 50 4: 824-830. doi:10.1016/j.ejca.2013.11.033


Author Van Den Berg, M. Johanneke
Mishra, Gita D.
Van Der Schouw, Yvonne T.
Herber-Gast, Gerrie-Cor M.
Title Vasomotor menopausal symptoms are not associated with incidence of breast cancer in a population-based cohort of mid-aged women
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
1879-0852
Publication date 2014-03
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.ejca.2013.11.033
Volume 50
Issue 4
Start page 824
End page 830
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Formatted abstract
Background Recently, two case-control studies showed that vasomotor menopausal symptoms (VMS), i.e. hot flushes (HF) and night sweats (NS), are associated with a decreased risk of breast cancer. Until now, however, no prior studies have prospectively examined the association between VMS and breast cancer incidence. We investigated this in a population-based cohort of mid-aged women in Australia.

Methods We included 11,297 women without a history of breast cancer aged 47-52 years from the Australian Longitudinal Study on Women's Health, surveyed every 3 years from 1998 to 2010. Information regarding first invasive breast cancer events and date of diagnosis was obtained from cancer registries. We determined the association between HF and NS and breast cancer occurrence before the subsequent survey, using time-dependent cox regression analysis, adjusting for time-varying lifestyle factors.

Results At baseline 33.1% of the women reported experiencing HF and 24.6% reported NS. During a mean follow-up of 13.7 years, 348 cases of breast cancer occurred. VMS were not associated with breast cancer; adjusted hazard ratios were 1.09; 95% confidence interval (CI) 0.87-1.35 for HF and 1.06; 95% CI 0.84-1.33 for NS. No significant interactions were found between each of body mass index, alcohol use, current hormone therapy use, menopausal status and VMS and breast cancer (p-values > 0.05).

Conclusions
We did not find an association between VMS and breast cancer incidence. Research in this area is scarce and additional large prospective population-based studies are required to confirm or refute these findings.
Keyword Breast cancer
Epidemiology
Vasomotor menopausal symptoms
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 18 December 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
 
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