Biodegradable core crosslinked star polymer nanoparticles as 19F MRI contrast agents for selective imaging

Wang, Kewei, Peng, Hui, Thurecht, Kristofer J., Puttick, Simon and Whittaker, Andrew K. (2014) Biodegradable core crosslinked star polymer nanoparticles as 19F MRI contrast agents for selective imaging. Polymer Chemistry, 5 5: 1760-1771. doi:10.1039/c3py01311a

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Author Wang, Kewei
Peng, Hui
Thurecht, Kristofer J.
Puttick, Simon
Whittaker, Andrew K.
Title Biodegradable core crosslinked star polymer nanoparticles as 19F MRI contrast agents for selective imaging
Journal name Polymer Chemistry   Check publisher's open access policy
ISSN 1759-9954
1759-9962
Publication date 2014-03-07
Year available 2013
Sub-type Article (original research)
DOI 10.1039/c3py01311a
Open Access Status File (Author Post-print)
Volume 5
Issue 5
Start page 1760
End page 1771
Total pages 12
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2014
Language eng
Abstract With the aim of developing stimuli-responsive imaging agents, we report here the synthesis of core crosslinked star (CCS) polymers and their evaluation as pH-sensitive 19F magnetic resonance imaging (19F MRI) contrast agents. Block copolymers consisting of poly(ethylene glycol)methyl ether methacrylate (PPEGMA) as the first block and a copolymer of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and 2,2,2-trifluoroethyl methacrylate (TFEMA) as the second block were synthesised using RAFT polymerisation. The polymerisation kinetics were studied in detail. The block copolymers were then used as arm precursors for the arm-first synthesis of CCS polymers through RAFT dispersion polymerisation. The synthetic conditions were investigated and optimised. CCS polymers with a degradable core were also synthesised and evaluated as 19F MRI contrast agents. The degradation of the core was confirmed by treatment with various reducing agents. The particle size, 19F NMR signal and relaxation times as well as 19F MRI imaging performance of the CCS polymers were studied at a range of value of solution pH. Significant enhancement of the image intensity was observed when the pH was decreased from 8 to 5, indicating that the CCS nanoparticles could be used as 19F MRI contrast agents for the detection of the acidic environment within tumour tissue.
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