A comprehensive assessment of parental age and psychiatric disorders

McGrath, John J., Petersen, Liselotte, Agerbo, Esben, Mors, Ole, Mortensen, Preben Bo and Pedersen, Carsten Bocker (2014) A comprehensive assessment of parental age and psychiatric disorders. JAMA Psychiatry, 74 3: 301-309. doi:10.1001/jamapsychiatry.2013.4081

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Author McGrath, John J.
Petersen, Liselotte
Agerbo, Esben
Mors, Ole
Mortensen, Preben Bo
Pedersen, Carsten Bocker
Title A comprehensive assessment of parental age and psychiatric disorders
Journal name JAMA Psychiatry   Check publisher's open access policy
ISSN 2161-622X
Publication date 2014-01-22
Year available 2014
Sub-type Article (original research)
DOI 10.1001/jamapsychiatry.2013.4081
Open Access Status File (Publisher version)
Volume 74
Issue 3
Start page 301
End page 309
Total pages 9
Place of publication Chicago, IL United States
Publisher American Medical Association
Collection year 2015
Language eng
Formatted abstract
 IMPORTANCE There has been recent interest in the findings that the offspring of older fathers have an increased risk of both de novo mutations and neuropsychiatric disorders. However, the offspring of younger parents are also at risk for some adverse mental health outcomes.

OBJECTIVE To determine the association between maternal and paternal age and a comprehensive range of mental health disorders.

DESIGN, SETTING, AND PARTICIPANTS A comprehensive, population-based record linkage study using the Danish Psychiatric Central Research Register from January 1, 1995, through December 31, 2011. A total of 2 894 688 persons born in Denmark from January 1, 1955, through December 31, 2006, were followed up during the study period.

EXPOSURES Maternal and paternal age at the time of offspring’s birth.

MAIN OUTCOMES AND MEASURES We examined a broad range ofInternational Classification of Diseases–defined mental disorders, including substance use; schizophrenia and related disorders; mood disorders; neurotic, stress-related, and somatoform disorders; eating disorders; specific personality disorders; and a range of developmental and childhood
disorders. The incidence rate ratios for each mental disorder outcome were estimated by log linear Poisson regression with adjustments for the calendar period, age, sex, and age of the other parent.

RESULTS The cohort was observed for 42.7 million person-years, during which 218 441 members of the cohort had their first psychiatric contact for any psychiatric disorder. Based on the overall risk of psychiatric disorders, the offspring of younger and older parents were at increased risk compared with those of parents aged 25 to 29 years. When the offspring were examined for particular disorders, the nature of the relationship changed. For example, the offspring of older fathers were at an increased risk of schizophrenia and related disorders, mental retardation, and autism spectrum disorders. In contrast, the offspring of young mothers (and to a lesser extent young fathers) were at an increased risk for substance use
disorders, hyperkinetic disorders, and mental retardation.

CONCLUSIONS AND RELEVANCE The offspring of younger mothers and older fathers are at risk for different mental health disorders. These differences can provide clues to the complex risk architecture underpinning the association between parental age and the mental health of offspring.
Keyword Danish National Registry
Maternal Age
Neuropsychiatric disease
Paternal Age
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 46 times in Scopus Article | Citations
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Created: Thu, 27 Feb 2014, 10:51:17 EST by Sheila Cleary on behalf of Psychiatry - Royal Brisbane and Women's Hospital