Different tau epitopes define Aβ42-mediated tau insolubility

Pennanen, Luis and Gotz, Juergen (2005) Different tau epitopes define Aβ42-mediated tau insolubility. Biochemical and Biophysical Research Communications, 337 4: 1097-1101. doi:10.1016/j.bbrc.2005.09.168


Author Pennanen, Luis
Gotz, Juergen
Title Different tau epitopes define Aβ42-mediated tau insolubility
Formatted title
Different tau epitopes define Aβ42-mediated tau insolubility
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
1090-2104
Publication date 2005-12-02
Sub-type Article (original research)
DOI 10.1016/j.bbrc.2005.09.168
Open Access Status Not yet assessed
Volume 337
Issue 4
Start page 1097
End page 1101
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Alzheimer's disease (AD) is characterized by extracellular β-amyloid (Aβ42)-containing plaques and intracellular neurofibrillary tangles. The latter are composed of hyperphosphorylated filamentous aggregates of the microtubule-associated protein tau. Previously we demonstrated pathological interactions between these two histopathological hallmarks using human SH-SY5Y neuroblastoma cells overexpressing wild-type and mutant forms of human tau. Exposure to pre-aggregated forms of Aβ42 caused both the formation of AD-like tau-containing filaments and a decreased solubility of tau, both of which were prevented by mutating the S422 phospho-epitope of tau. Here, we expressed additional tau mutants in SH-SY5Y cells to assess the role of phosphorylation and cleavage sites of tau in tau aggregation. We found that the Aβ42-mediated decrease in tau solubility depends on the interplay of distinct phospho-epitopes of tau and not only on phosphorylation of the S422 epitope.
Keyword β-Amyloid
Alzheimer's disease
Mutagenesis
Neurofibrillary tangles
Phospho-epitope
SH-SY5Y neuroblastoma cells
Tau
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Ageing Dementia Research Publications
 
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