Glial cells under physiologic and pathologic conditions

Kurosinski, Pascal, Biol, Dipl and Gotz, Jurgen (2002) Glial cells under physiologic and pathologic conditions. JAMA Neurology, 59 10: 1524-1528. doi:10.1001/archneur.59.10.1524

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Author Kurosinski, Pascal
Biol, Dipl
Gotz, Jurgen
Title Glial cells under physiologic and pathologic conditions
Journal name JAMA Neurology   Check publisher's open access policy
ISSN 2168-6149
2168-6157
Publication date 2002-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1001/archneur.59.10.1524
Open Access Status File (Publisher version)
Volume 59
Issue 10
Start page 1524
End page 1528
Total pages 5
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Abstract Glial cells have long been considered to play roles in the nervous system that are unexciting compared with those of neurons. They provide neurons with nutrients, guide migrating neurons and their precursors during development, and dispose of the brain's "waste." Recent evidence, however, suggests that glial cells play more sophisticated, neuronlike roles. They integrate neuronal input, modulate synaptic activity, and process signals related to learning and memory. These findings have significant implications for humans with neurodegenerative diseases. In addition to activation on nervous system injury and during neuronal degeneration, glial cells also degenerate in several neurodegenerative diseases. Therefore, glial cell loss may contribute to the impairment of learning and memory. Therapeutic approaches to combat human neurodegenerative diseases thus need to restore the function of both neurons and glial cells.
Keyword Glial cells
Physiologic
Pathologic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
 
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