Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice

Pennanen, Luis, Welzl, Hans, D'Adamo, Patrizia, Nitsch, Roger M. and Gotz, Juergen (2004) Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiology of Disease, 15 3: 500-509. doi:10.1016/j.nbd.2003.11.020


Author Pennanen, Luis
Welzl, Hans
D'Adamo, Patrizia
Nitsch, Roger M.
Gotz, Juergen
Title Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
Journal name Neurobiology of Disease   Check publisher's open access policy
ISSN 0969-9961
1095-953X
Publication date 2004-04
Sub-type Article (original research)
DOI 10.1016/j.nbd.2003.11.020
Open Access Status Not yet assessed
Volume 15
Issue 3
Start page 500
End page 509
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract Neurofibrillary tangles, insoluble protein deposits composed of filamentous tau aggregates, are neuropathological hallmarks of Alzheimer's disease and familial frontotemporal dementia (FTDP-17). Transgenic mice expressing the FTDP-17 mutation P301L of tau recapitulate key features of the human pathology, that is, tau proteins aggregate and neurofibrillary tangles begin to appear in the amygdala at 6 months of age. To detect early signs of tau aggregate-associated changes, we investigated behavioral alterations and cognitive deficits in such mice using an amygdala-specific test battery for anxiety-related and cognitive behavior. P301L mice had anxiety levels not different from wild-types, but their exploratory behavior was significantly increased. Acquisition of a fear response to tone and context as well as taste aversion was comparable to wild-types. However, extinction of a conditioned taste aversion was significantly accelerated. We conclude that already aggregation of tau proteins not yet accompanied by massive formation of neurofibrillary tangles causes selective behavioral deficits.
Keyword Alzheimer's disease
Amygdala
Conditioned taste aversion
Extinction
Frontotemporal dementia
Neurofibrillary tangles
Tau
Transgenic mice
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Ageing Dementia Research Publications
 
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