Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils

Goetz, J., Chen, F., Van Dorpe, J. and Nitsch, R. M. (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science, 293 5534: 1491-1495. doi:10.1126/science.1062097


Author Goetz, J.
Chen, F.
Van Dorpe, J.
Nitsch, R. M.
Title Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2001-08-24
Sub-type Article (original research)
DOI 10.1126/science.1062097
Open Access Status Not yet assessed
Volume 293
Issue 5534
Start page 1491
End page 1495
Total pages 5
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Formatted abstract
β-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation is unclear. Injection of β-amyloid Aβ42 fibrils into the brains of P301L mutant tau transgenic mice caused fivefold increases in the numbers of NFTs in cell bodies within the amygdala from where neurons project to the injection sites. Gallyas silver impregnation identified NFTs that contained tau phosphorylated at serine 212/threonine 214 and serine 422. NFTs were composed of twisted filaments and occurred in 6-month-old mice as early as 18 days after Aβ42 injections. Our data support the hypothesis that Aβ42 fibrils can accelerate NFT formation in vivo.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Ageing Dementia Research Publications
 
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