Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-toxicity

Eckert, Anne, Schmitt, Karen and Gotz, Jurgen (2011) Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-toxicity. Alzheimer's Research and Therapy, 3 3: 15.1-15.11. doi:10.1186/alzrt74

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ324050_OA.pdf Full text (open access) application/pdf 2.08MB 0

Author Eckert, Anne
Schmitt, Karen
Gotz, Jurgen
Title Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-toxicity
Journal name Alzheimer's Research and Therapy   Check publisher's open access policy
ISSN 1758-9193
Publication date 2011-05-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/alzrt74
Open Access Status File (Publisher version)
Volume 3
Issue 3
Start page 15.1
End page 15.11
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates of amyloid- (A)) and neurofibrillary tangles (aggregates of tau) and is accompanied by mitochondrial dysfunction, but the mechanisms underlying this dysfunction are poorly understood. In this review, we discuss the critical role of mitochondria and the close inter-relationship of this organelle with the two main pathological features in the pathogenic process underlying AD. Moreover, we summarize evidence from AD post-mortem brain as well as cellular and animal AD models showing that A and tau protein trigger mitochondrial dysfunction through a number of pathways, such as impairment of oxidative phosphorylation, elevation of reactive oxygen species production, alteration of mitochondrial dynamics, and interaction with mitochondrial proteins. A vicious cycle as well as several vicious circles within the cycle, each accelerating the other, can be drawn, emphasizing the synergistic deterioration of mitochondria by tau and A.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 56 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 26 Feb 2014, 08:28:27 EST by System User on behalf of Queensland Brain Institute