Cortical gyrification reductions and subcortical atrophy in Parkinson's disease

Zhang, Yuanchao, Zhang, Jiuqun, Xu, Jinping, Wu, Xiu, Zhang, Yanling, Feng, Hua, Wang, Jian and Jiang, Tianzi (2014) Cortical gyrification reductions and subcortical atrophy in Parkinson's disease. Movement Disorders, 29 1: 122-126. doi:10.1002/mds.25680

Author Zhang, Yuanchao
Zhang, Jiuqun
Xu, Jinping
Wu, Xiu
Zhang, Yanling
Feng, Hua
Wang, Jian
Jiang, Tianzi
Title Cortical gyrification reductions and subcortical atrophy in Parkinson's disease
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
Publication date 2014-01
Year available 2013
Sub-type Article (original research)
DOI 10.1002/mds.25680
Open Access Status
Volume 29
Issue 1
Start page 122
End page 126
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher Jossey Bass
Collection year 2014
Language eng
Formatted abstract
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms. Previous morphometric studies of PD were mainly conducted by measuring gray matter volume and cortical thickness, and little attention has been paid to the morphology of the cortical surface.

Methods: Using a surface-based local gyrification index (lGI), this study compared the cortical gyrification patterns of 37 PD patients and 34 matched healthy controls. Volumetric analyses also were performed on the subcortical structures.

Results: Compared with the control group, patients with PD had significantly reduced cortical gyrification in multiple brain regions, which the authors speculated were associated with disruptions in white matter connectivity and suboptimal intracortical organization. In addition, subcortical volume atrophy was identified in the bilateral hippocampus and bilateral caudate of the patients with PD.

Conclusions: Further studies are needed to identify the clinical correlates of the structural abnormalities observed in PD.
Keyword Cortical gyrification
Intracortical organization
Local gyrification index
Parkinson's disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 7 October 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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