Cardenolide Glycosides from Elaeodendron australe var. integrifolium

Butler, Mark S., Towerzey, Leanne, Pham, Ngoc B., Hyde, Edward, Wadi, Sao Khemar, Guymer, Gordon P. and Quinn, Ronald J. (2014) Cardenolide Glycosides from Elaeodendron australe var. integrifolium. Phytochemistry, 98 160-163. doi:10.1016/j.phytochem.2013.11.024

Author Butler, Mark S.
Towerzey, Leanne
Pham, Ngoc B.
Hyde, Edward
Wadi, Sao Khemar
Guymer, Gordon P.
Quinn, Ronald J.
Title Cardenolide Glycosides from Elaeodendron australe var. integrifolium
Formatted title
Cardenolide Glycosides from Elaeodendron australe var. integrifolium
Journal name Phytochemistry   Check publisher's open access policy
ISSN 0031-9422
Publication date 2014-02
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.phytochem.2013.11.024
Open Access Status
Volume 98
Start page 160
End page 163
Total pages 4
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Formatted abstract
Extracts from dried leaf and stems of Elaeodendron australe var. integrifolium (Celastraceae) collected in South East Queensland, Australia, were active in an assay that measured Ca2+ driven expression of IL-2/luciferase designed to identify inhibitors of the ICRAC channel. Bioassay-guided isolation using C18 and polyamide column chromatography, HPLC (Phenyl and C18) and centrifugal partition chromatography (CPC) led to the isolation of digitoxigenin (1) and three cardenolide glycosides, glucoside 2, quinovoside 3 and the new natural product xyloside 4, as the active components with low nM activity in the reporter assay.
Keyword Cardenolide
Centrifugal partition chromatography
Elaeodendron australe var. integrifolium
Interleukin-2 (IL-2)/luciferase inhibitor
Ion channel
Na+/K +-ATPase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
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