Evidence for positive selection of taurine genes within a QTL region on chromosome X associated with testicular size in Australian Brahman cattle

Lyons, Russell E., Loan, Nguyen To, Dierens, Leanne, Fortes, Marina R. S., Kelly, Matthew, McWilliam, Sean S., Li, Yutao, Bunch, Rowan J., Harrison, Blair E., Barendse, William, Lehnert, Sigrid A. and Moore, Stephen S. (2014) Evidence for positive selection of taurine genes within a QTL region on chromosome X associated with testicular size in Australian Brahman cattle. BMC Genetics, 15 6.1-6.10. doi:10.1186/1471-2156-15-6


Author Lyons, Russell E.
Loan, Nguyen To
Dierens, Leanne
Fortes, Marina R. S.
Kelly, Matthew
McWilliam, Sean S.
Li, Yutao
Bunch, Rowan J.
Harrison, Blair E.
Barendse, William
Lehnert, Sigrid A.
Moore, Stephen S.
Title Evidence for positive selection of taurine genes within a QTL region on chromosome X associated with testicular size in Australian Brahman cattle
Journal name BMC Genetics   Check publisher's open access policy
ISSN 1471-2156
Publication date 2014-01-10
Sub-type Article (original research)
DOI 10.1186/1471-2156-15-6
Open Access Status DOI
Volume 15
Start page 6.1
End page 6.10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2015
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
Formatted abstract
Background: Previous genome-wide association studies have identified significant regions of the X chromosome associated with reproductive traits in two Bos indicus-influenced breeds: Brahman cattle and Tropical Composites. Two QTL regions on this chromosome were identified in both breeds as strongly associated with scrotal circumference measurements, a reproductive trait previously shown to be useful for selection of young bulls. Scrotal circumference is genetically correlated with early age at puberty in both male and female offspring. These QTL were located at positions 69-77 and 81-92 Mb respectively, large areas each to which a significant number of potential candidate genes were mapped.

Results: To further characterise these regions, a bioinformatic approach was undertaken to identify novel non-synonymous SNP within the QTL regions of interest in Brahman cattle. After SNP discovery, we used conventional molecular assay technologies to perform studies of two candidate genes in both breeds. Non-synonymous SNP mapped to Testis-expressed gene 11 (Tex11) were associated (P < 0.001) with scrotal circumference in both breeds, and associations with percentage of normal sperm cells were also observed (P < 0.05). Evidence for recent selection was found as Tex11 SNP form a haplotype segment of Bos taurus origin that is retained within Brahman and Tropical Composite cattle with greatest reproductive potential.

Conclusions: Association of non-synonymous SNP presented here are a first step to functional genetic studies. Bovine species may serve as a model for studying the role of Tex11 in male fertility, warranting further in-depth molecular characterisation. 
Keyword Association study
Bovine
Candidate gene
Haplotype analysis
Reproductive trait
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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