Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis

Khabbazi S., Jacques R.O., Moyano Cardaba C. and Mueller A. (2013) Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis. Cell Biochemistry and Function, 31 4: 312-318. doi:10.1002/cbf.2901


Author Khabbazi S.
Jacques R.O.
Moyano Cardaba C.
Mueller A.
Title Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis
Journal name Cell Biochemistry and Function   Check publisher's open access policy
ISSN 0263-6484
1099-0844
Publication date 2013-06
Year available 2012
Sub-type Article (original research)
DOI 10.1002/cbf.2901
Volume 31
Issue 4
Start page 312
End page 318
Total pages 7
Place of publication West Sussex United Kingdom
Publisher John Wiley & Sons
Collection year 2014
Language eng
Subject 1303 Specialist Studies in Education
1307 Cell Biology
1308 Clinical Biochemistry
Abstract Chemokine receptors induce cell migration, but the molecular basis of the signal cascade involved is not completely understood. Therefore, we investigated here the molecular mechanisms of CCL3-, CCL5- and CCL8-induced cells migration and investigated whether the Janus kinase/signal transducer and activator of transcription (STAT) signalling pathway is involved. Some STAT3 inhibitors, like Cucurbitacin I, destroy the actin cytoskeleton inside the cells and therefore prevent any cellular migration. However, for inhibitors that do not affect the actin cytoskeleton or induce cell death, we show that chemokine-induced cell migration is not dependent on activation of Janus kinase 2 or STAT3.
Keyword Actin polymerization
Chemokine receptor
JAK
Migration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
 
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