Improved Fmoc Synthesis of Bradykinin

Stephenson, Rachel J., Plieger, Paul G. and Harding, David R. K. (2011) Improved Fmoc Synthesis of Bradykinin. Protein and Peptide Letters, 18 9: 952-955. doi:10.2174/092986611796011509


Author Stephenson, Rachel J.
Plieger, Paul G.
Harding, David R. K.
Title Improved Fmoc Synthesis of Bradykinin
Journal name Protein and Peptide Letters   Check publisher's open access policy
ISSN 0929-8665
1875-5305
Publication date 2011-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.2174/092986611796011509
Volume 18
Issue 9
Start page 952
End page 955
Total pages 4
Place of publication Bussum The Netherlands
Publisher Bentham Science Publishers Ltd
Collection year 2012
Language eng
Formatted abstract
 Two arginine side-chain protecting groups, NG-4-methoxy-2,3,6-trimethylbenzensulfonyl group (Mtr) and NG- 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pmc), have been investigated at both the Arg1 and/or Arg9 position of the bioactive peptide, Bradykinin using Fluorenylmethyloxycarbonyl (Fmoc) Solid Phase Peptide Synthesis. A more efficient synthesis of the peptide has been found when a combination of Arg(Mtr) is present at position 1 and Arg(Pmc) is present at position 9 giving a cleaved pure yield of 52%.
Keyword Bradykinin
Drug delivery
Fmoc solid phase peptide synthesis
Phase peptide synthesis
Antagonists
Cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 13 Feb 2014, 14:11:29 EST by Rachel Stephenson on behalf of School of Chemistry & Molecular Biosciences