Predictors of re-epithelialization in pediatric burn

Brown, Nadia J., Kimble, Roy M., Gramotnev, Galina, Rodger, Sylvia and Cuttle, Leila (2013) Predictors of re-epithelialization in pediatric burn. Burns, 40 4: 751-758. doi:10.1016/j.burns.2013.09.027

Author Brown, Nadia J.
Kimble, Roy M.
Gramotnev, Galina
Rodger, Sylvia
Cuttle, Leila
Title Predictors of re-epithelialization in pediatric burn
Journal name Burns   Check publisher's open access policy
ISSN 0305-4179
Publication date 2013
Sub-type Article (original research)
DOI 10.1016/j.burns.2013.09.027
Open Access Status
Volume 40
Issue 4
Start page 751
End page 758
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Formatted abstract
Introduction An important treatment goal for burn wounds is to promote early wound closure. This study identifies factors associated with delayed re-epithelialization following pediatric burn.

Methods Data were collected from August 2011 to August 2012, at a pediatric tertiary burn center. A total of 106 burn wounds were analyzed from 77 participants aged 4–12 years. Percentage of wound re-epithelialization at each dressing change was calculated using Visitrak™. Mixed effect regression analysis was performed to identify the demographic factors, wound and clinical characteristics associated with delayed re-epithelialization.

Results Burn depth determined by laser Doppler imaging, ethnicity, pain scores, total body surface area (TBSA), mechanism of injury and days taken to present to the burn center were significant predictors of delayed re-epithelialization, accounting for 69% of variance. Flame burns delayed re-epithelialization by 39% compared to all other mechanisms (p = 0.003). When initial presentation to the burn center was on day 5, burns took an average of 42% longer to re-epithelialize, compared to those who presented on day 2 post burn (p < 0.000). Re-epithelialization was delayed by 14% when pain scores were reported as 10 (on the FPS-R), compared to 4 on the first dressing change (p = 0.015) for children who did not receive specialized preparation/distraction intervention. A larger TBSA was also a predictor of delayed re-epithelialization (p = 0.030). Darker skin complexion re-epithelialized 25% faster than lighter skin complexion (p = 0.001).

Conclusions Burn depth, mechanism of injury and TBSA are always considered when developing the treatment and surgical management plan for patients with burns. This study identifies other factors influencing re-epithelialization, which can be controlled by the treating team, such as effective pain management and rapid referral to a specialized burn center, to achieve optimal outcomes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Wed, 12 Feb 2014, 14:50:16 EST by Matthew Lamb on behalf of School of Medicine