Potent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral candida species and the synergy with fluconazole against azole-resistant Candida albicans

Yan, Zhimin, Hua, Hong, Xu, Yanying and Samaranayake, Lakshman P. (2012) Potent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral candida species and the synergy with fluconazole against azole-resistant Candida albicans. Evidence-based Complementary and Alternative Medicine, 2012 106583.-106583.6. doi:10.1155/2012/106583


Author Yan, Zhimin
Hua, Hong
Xu, Yanying
Samaranayake, Lakshman P.
Title Potent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral candida species and the synergy with fluconazole against azole-resistant Candida albicans
Formatted title
Potent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral Candida species and the synergy with fluconazole against azole-resistant Candida albicans
Journal name Evidence-based Complementary and Alternative Medicine   Check publisher's open access policy
ISSN 1741-427X
1741-4288
Publication date 2012
Sub-type Article (original research)
DOI 10.1155/2012/106583
Open Access Status DOI
Volume 2012
Start page 106583.
End page 106583.6
Total pages 6
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Language eng
Abstract This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjgren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjgren's syndrome patients. The MIC values ranged from 16 to 128 μg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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