Phenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohort

Samaranayake, Y. H., Samaranayake, L. P., Yau, J. Y. Y., Dassanayake, R. S., Li, T. K. L. and Anil, S. (2003) Phenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohort. APMIS, 111 2: 329-337. doi:10.1034/j.1600-0463.2003.1110206.x


Author Samaranayake, Y. H.
Samaranayake, L. P.
Yau, J. Y. Y.
Dassanayake, R. S.
Li, T. K. L.
Anil, S.
Title Phenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohort
Formatted title
Phenotypic diversity of oral C. albicans isolated on single and sequential visits in an HIV-infected Chinese cohort
Journal name APMIS   Check publisher's open access policy
ISSN 0903-4641
1600-0463
Publication date 2003-02-01
Year available 2003
Sub-type Article (original research)
DOI 10.1034/j.1600-0463.2003.1110206.x
Open Access Status Not yet assessed
Volume 111
Issue 2
Start page 329
End page 337
Total pages 9
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
HIV-infected individuals maintain multiple oral C. albicans strains over time that are thought to undergo microevolution in terms of both phenotypic and genotypic features. To study this phenomenon, a 12-month prospective study was conducted in a cohort of 16 HIV-infected ethnic Chinese individuals with (A) and without (B) symptoms of oropharyngeal candidiasis to evaluate the phenotype distribution among oral C. albicans isolates during disease progression. Oral rinse samples were obtained and up to five C. albicans colony-forming units were selected per each visit, during the one year period of multiple visits. The isolates were phenotyped using two commercially available biotyping kits, the API 20C system, API ZYM system, and a plate test for resistance to boric acid. A total of 261 C. albicans strains in group A were differentiated into 67 biotypes, while 42 biotypes were seen amongst the 182 isolates from group B. The major biotypes in the two groups were similar and were in decreasing order of prevalence J1R, J1S, J6S, J6R, J2S, K1S, J10R, K1R, and K6R; 48 different biotypes were seen in group A and 24 in group B, with some uniquely represented in each group, leading to a significant association between the prevalence of the biotypes J1S and J2S and symptomatic candidiasis (p<0.05). Taken together this study illustrates the wide phenotypic spectrum of oral C. albicans associated with HIV-infection.
Keyword Biotypes
Candida albicans
HIV-infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
MVM records
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 12 Feb 2014, 09:15:23 EST by System User on behalf of Scholarly Communication and Digitisation Service