Experimental oral candidiasis in animal models

Samaranayake, Yuthika H. and Samaranayake, Lakshman P. (2001) Experimental oral candidiasis in animal models. Clinical Microbiology Reviews, 14 2: 398-429. doi:10.1128/CMR.14.2.398-429.2001


Author Samaranayake, Yuthika H.
Samaranayake, Lakshman P.
Title Experimental oral candidiasis in animal models
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 0893-8512
1098-6618
Publication date 2001-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/CMR.14.2.398-429.2001
Open Access Status Not yet assessed
Volume 14
Issue 2
Start page 398
End page 429
Total pages 32
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Oral candidiasis is as much the final outcome of the vulnerability of the host as of the virulence of the invading organism. We review here the extensive literature on animal experiments mainly appertaining to the host predisposing factors that initiate and perpetuate these infections. The monkey, rat, and mouse are the choice models for investigating oral candidiasis, but comparisons between the same or different models appear difficult, because of variables such as the study design, the number of animals used, their diet, the differences in Candida strains, and the duration of the studies. These variables notwithstanding, the following could be concluded. (i) The primate model is ideal for investigating Candida-associated denture stomatitis since both erythematous and pseudomembranous lesions have been produced in monkey with prosthetic plates; they are, however, expensive and difficult to obtain and maintain. (ii) The rat model (both Sprague-Dawley and Wistar) is well proven for observing chronic oral candidal colonization and infection, due to the ease of breeding and handling and their ready availability. (iii) Mice are similar, but in addition there are well characterized variants simulating immunologic and genetic abnormalities (e.g., athymic, euthymic, murine-acquired immune deficiency syndrome, and severe combined immunodeficient models) and hence are used for short-term studies relating the host immune response and oral environment in ecological and microbiological terms is yet to be described. Until such a model is developed, researchers should pay attention to standardization of the experimental protocols described here to obtain broadly comparable and meaningful data.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Dentistry Publications
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