Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand

Reichart, P. A., Samaranayake, L. P., Bendick, Ch., Schmidt-Westhausen, A. M. and Jayatilake, J. A. M. S. (2007) Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand. Journal of Oral Pathology and Medicine, 36 6: 342-346. doi:10.1111/j.1600-0714.2007.00535.x


Author Reichart, P. A.
Samaranayake, L. P.
Bendick, Ch.
Schmidt-Westhausen, A. M.
Jayatilake, J. A. M. S.
Title Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand
Formatted title
Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand
Journal name Journal of Oral Pathology and Medicine   Check publisher's open access policy
ISSN 0904-2512
1600-0714
Publication date 2007-07
Sub-type Article (original research)
DOI 10.1111/j.1600-0714.2007.00535.x
Open Access Status Not yet assessed
Volume 36
Issue 6
Start page 342
End page 346
Total pages 5
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background: Leprosy is a chronic bacterial infection which may lead to significant orofacial morbidity. However, reports on the oral mycotic flora of leprosy patients are rare. The aim of the current study was to explore the oral yeast carriage in two groups of leprosy patients.

Methods: 40 Cambodian (seven men, 33 women) and 48 Thai (14 men, 34 women) leprosy patients from Leprosy Rehabilitation Centre Khien Kleang, Phnom Penh, Cambodia and McKean Rehabilitation Center, Chiangmai, Thailand were randomly selected and their demographic data and clinical history were recorded. Tongue and palatal swabs of each patient were collected using sterile Fungi-Quick swabs (Hain Diagnostika, Nehren, Germany) and they were cultured aerobically on Sabouraud's dextrose agar and CHROMAgar (CHROMagar, Paris, France). Yeast were identified by germ tube, chlamydospore production, and assimilation tests (API 20C AUX, Bio-Merieux, Marcy l'Etoile, France) and reconfirmed using APILAB Plus system (Bio-Merieux).

Results: Two groups (Cambodian and Thai) had median age of 35 and 64 years. They had been with leprosy for median durations of 17.7 and 38.9 years (P < 0.05), respectively. Overall yeast carriage in two cohorts were 80% and 93.75%. Candida albicans had highest carriage rate in either group (65.6%, 44.4%). Candida krusei and C. glabrata existed as second-line colonizers after C. albicans. Candida glabrata carriage was significantly higher in Thai patients (P < 0.05). Multispecies carriage was seen in three Cambodian (9.4%) and five Thai (11.5%) patients.

Conclusions: This study indicates high oral yeast carriage in leprosy patients. Candida albicans remains predominant while C. krusei and C. glabrata are second-line oral colonizers. Co-inhabitation of multiple yeast species is also noted in these patients' oral mycotic flora.
Keyword Cambodia
Candida species
Leprosy
Oral
Thailand
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
MVM records
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 12 Feb 2014, 08:48:34 EST by System User on behalf of Scholarly Communication and Digitisation Service