Phenotypic evaluation of the effect of anaerobiosis on some virulence attributes of Candida albicans

Ribeiro Rosa, Edvaldo Antonio, Nunes Rached, Rodrigo, Aparecido Ignacio, Sergio, Takaki Rosa, Rosimeire, Jose da Silva, Wander, Yau, Joyce Yick Yee and Samaranayake, Lakshman Perera (2008) Phenotypic evaluation of the effect of anaerobiosis on some virulence attributes of Candida albicans. Journal of Medical Microbiology, 57 10: 1277-1281. doi:10.1099/jmm.0.2008/001107-0


Author Ribeiro Rosa, Edvaldo Antonio
Nunes Rached, Rodrigo
Aparecido Ignacio, Sergio
Takaki Rosa, Rosimeire
Jose da Silva, Wander
Yau, Joyce Yick Yee
Samaranayake, Lakshman Perera
Title Phenotypic evaluation of the effect of anaerobiosis on some virulence attributes of Candida albicans
Formatted title
Phenotypic evaluation of the effect of anaerobiosis on some virulence attributes of Candida albicans 
Journal name Journal of Medical Microbiology   Check publisher's open access policy
ISSN 0022-2615
1473-5644
Publication date 2008
Sub-type Article (original research)
DOI 10.1099/jmm.0.2008/001107-0
Open Access Status
Volume 57
Issue 10
Start page 1277
End page 1281
Total pages 5
Place of publication Reading, Berks, United Kingdom
Publisher Society for General Microbiology
Language eng
Abstract The current assumption that Candida albicans is a facultatively anaerobic organism has been widely accepted since its recovery from anoxic sites became common. However, the link between anaerobiosis and virulence remains uncertain. This study investigated the differential cell-surface hydrophobicity (CSH) using a hydrocarbon/water partition technique and analysed the differential secretion rates of secretory aspartyl proteases (Saps), esterase, chondroitinase and haemolysins of C. albicans strains recovered from periodontal pockets and non-periodontium-related intra-oral sites. For the enzymic tests, all strains from both sets were grown under aerobic and anaerobic conditions and the harvested cells were inoculated onto suitable normal or pre-reduced culture media in the presence or absence of molecular oxygen, respectively. The results showed that no variations were perceptible for CSH and chondroitinase (P > 0.05). The secretion rates of esterase and haemolysins strongly decreased in an anoxic environment (P <0.0001). However, a consistent increment (P <0.0001) in Sap secretion was detected when cultures were grown under anaerobic conditions. Based on these results, it is suggested that the oxygen concentration in the atmosphere surrounding cells exerts a variable influence on the virulence attributes of C. albicans.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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