In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

Kang, K., Wong, K.-S., Jayampath Seneviratne, C., Samaranayake, L. P., Fong, W.-P. and Tsang, P. W.-K. (2010) In vitro synergistic effects of metergoline and antifungal agents against Candida krusei. Mycoses, 53 6: 495-499. doi:10.1111/j.1439-0507.2009.01747.x


Author Kang, K.
Wong, K.-S.
Jayampath Seneviratne, C.
Samaranayake, L. P.
Fong, W.-P.
Tsang, P. W.-K.
Title In vitro synergistic effects of metergoline and antifungal agents against Candida krusei
Formatted title
In vitro synergistic effects of metergoline and antifungal agents against Candida krusei
Journal name Mycoses   Check publisher's open access policy
ISSN 0933-7407
1439-0507
Publication date 2010
Sub-type Article (original research)
DOI 10.1111/j.1439-0507.2009.01747.x
Open Access Status
Volume 53
Issue 6
Start page 495
End page 499
Total pages 5
Place of publication Berlin, Germany
Publisher Wiley-Blackwell
Language eng
Abstract Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml -1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.
Keyword Candida krusei
Metergoline
Phospholipase
Synergism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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