Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole

Anil, S. and Samaranayake, L. P. (2002) Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole. Oral Diseases, 8 4: 199-206. doi:10.1034/j.1601-0825.2002.01818.x


Author Anil, S.
Samaranayake, L. P.
Title Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole
Formatted title
Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole
Journal name Oral Diseases   Check publisher's open access policy
ISSN 1354-523X
1601-0825
Publication date 2002-07
Year available 2002
Sub-type Article (original research)
DOI 10.1034/j.1601-0825.2002.01818.x
Open Access Status Not yet assessed
Volume 8
Issue 4
Start page 199
End page 206
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective: To assess the antifungal activity of lysozyme and lactoferrin on 10 oral isolates each of Candida albicans and Candida tropicalis following their brief exposure (1 h) to subtherapeutic concentrations of two polyene drugs - nystatin, amphotericin B, and an azole -fluconazole.

Methods: Yeasts were sequentially exposed to sub-therapeutic concentrations of antifungals and then to either lysozyme or lactoferrin and the viability evaluated by quantifying colony-forming units.

Results: The exposure of both C. albicans and C. tropicalis isolates to all three antifungal agents significantly increased their susceptibility to lysozyme (P < 0.05) but not to lactoferrin. Exposure to the two polyene drugs had a lesser impact on the lysozyme susceptibility of both Candida species compared with the azole drug. Both interspecies and intraspecies sensitivity to lysozyme was noted and C. albicans was less susceptible than C. tropicalis.

Conclusions: Lysozyme, in addition to being a potent natural antifungal agent, may act synergistically with the studied antimycotics.
Keyword Antifungals
Candida
Lactoferrin
Lysozyme
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
MVM records
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 12 Feb 2014, 08:23:53 EST by System User on behalf of Scholarly Communication and Digitisation Service