Experimental superficial candidiasis on tissue models: Review article

Jayatilake, J. A. M. S. and Samaranayake, L. P. (2010) Experimental superficial candidiasis on tissue models: Review article. Mycoses, 53 4: 285-295. doi:10.1111/j.1439-0507.2010.01879.x


Author Jayatilake, J. A. M. S.
Samaranayake, L. P.
Title Experimental superficial candidiasis on tissue models: Review article
Journal name Mycoses   Check publisher's open access policy
ISSN 0933-7407
1439-0507
Publication date 2010
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1439-0507.2010.01879.x
Open Access Status
Volume 53
Issue 4
Start page 285
End page 295
Total pages 11
Place of publication Berlin, Germany
Publisher Wiley-Blackwell Verlag GmbH
Collection year 2010
Language eng
Subject 2708 Dermatology
2725 Infectious Diseases
Abstract Summary Candida species are common pathogens causing superficial mycoses primarily affecting the mucosa and the skin in humans. Crucial steps during pathogenesis of superficial candidiasis comprise fungal adhesion, colonisation and subsequent penetration of the respective tissues. Exploring these pathological events and perhaps fungal and tissue responses towards drug treatment is imperative in the management of this infection. Unfortunately, pathological biopsies of superficial candidiasis do not exhibit the early changes in the host-pathogen interaction as the tissues are already invaded by the fungi. In vivo experimental assessments of pathological processes of superficial candidiasis are also limited because of the difficulties in providing reproducible and comparable conditions in the host environment. Conversely, in vitro models have helped studying fungal-host interactions under more defined and controlled conditions. Some common in vitro models used to simulate superficial candidiasis are chick chorioallantoic membrane, mucosal explants and single layer or multiple layer cell cultures. Interestingly, these experimental approaches share advantages as well as disadvantages when compared with in vivo conditions. Hence, this review intends to discuss about the experimental superficial candidiasis produced in various tissue models and their advantages as well as disadvantages with a particular reference to further improvement of validity and reliability of such experiments.
Keyword Animal models
Candidiasis
Cell culture
Mucosal explants
Tissue culture
Tissue models
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Dentistry Publications
 
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