Brief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalis

Anil, S. and Samaranayake, L. P. (2003) Brief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalis. Chemotherapy, 49 5: 243-247. doi:10.1159/000072448


Author Anil, S.
Samaranayake, L. P.
Title Brief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalis
Formatted title
Brief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalis
Journal name Chemotherapy   Check publisher's open access policy
ISSN 0009-3157
1421-9794
Publication date 2003-09
Year available 2003
Sub-type Article (original research)
DOI 10.1159/000072448
Volume 49
Issue 5
Start page 243
End page 247
Total pages 5
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Formatted abstract
Background: Although the phospholipase activity is considered a potential virulence determinant of the pathogenic Candida species, the effect of antimycotics on this attribute is not known. Hence we evaluated the phospholipase activity in 10 isolates each of Candida albicans and Candida tropicalis, after their exposure to antifungals.

Methods: The impact of antimycotics on phospholipase activity was also assessed after exposure of the isolates to sub-minimum inhibitory concentrations of nystatin, amphotericin B and fluconazole.

Results: All Candida isolates investigated exhibited phospholipase activity (Pz). In general C. albicans showed relatively higher Pz activity than C. tropicalis, and exposure of the isolates to antimycotics led to a significant (p < 0.05) reduction in the phospholipase activity. Nystatin and amphotericin B, but not fluconazole, significantly reduced the phospholipase activity of both Candida species.

Conclusion: These observations, while confirming the higher virulence of C. albicans relative to C. tropicalis, demonstrate for the first time the effect of antifungal agents on extracellular phospholipases of these common opportunistic pathogens. 
Keyword Antifungal agents
Candida
HIV infection
Phospholipase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
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