The effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort

Ceballos-Salobrena, Alejandro, Gaitain-Cepeda, Luis, Ceballos-Garcia, Laura and Samaranayake, Lakshman P. (2004) The effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 97 3: 345-350. doi:10.1016/j.tripleo.2003.09.016


Author Ceballos-Salobrena, Alejandro
Gaitain-Cepeda, Luis
Ceballos-Garcia, Laura
Samaranayake, Lakshman P.
Title The effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort
Journal name Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology   Check publisher's open access policy
ISSN 1079-2104
2212-4403
2212-4411
Publication date 2004-03-01
Year available 2004
Sub-type Article (original research)
DOI 10.1016/j.tripleo.2003.09.016
Open Access Status Not yet assessed
Volume 97
Issue 3
Start page 345
End page 350
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Objective: To investigate the temporal changes in the prevalence of oral candidiasis in a cohort of Spanish human immunodeficiency virus (HIV)-infected individuals, before and after the introduction of highly active antiretroviral therapy (HAART).

Study design: Retrospective analysis of a clinical database from "Carlos Haya" Hospital, Málaga, Spain, from 1995 to 2000. The prevalence of oral candidiasis was assessed in 807 HIV/AIDS patients and the temporal progression of its major variants evaluated using a linear regression model.

Results: Overall oral candidiasis was prevalent in 30.0% to 48.3% of the cohort throughout and no significant variation in its incidence was noted during the study period. Prevalence of erythematous candidiasis increased from 24.5% (1995) to 45.0% (2000) and pseudomembranous candidiasis decreased from 22.4% (1995) to 5.2% (2000) (P<.05). Hyperplastic candidiasis was not detected in the cohort after the introduction of HAART therapy.

Conclusions: Although oral candidiasis in HIV-infected Spanish individuals has not decreased significantly after the introduction of HAART, there appears to be a significant reduction in hyperplastic and pseudomembranous variants of the disease with a compensatory increase in erythematous candidiasis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
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