The Glial Differentiation Factor Nuclear Factor One B (Nfib) Induces Differentiation and Inhibits Growth of Glioblastoma.

Stringer, Brett, Day, Bryan, Barry, Guy, Piper, Michael, Jamieson, Paul, Ensbey, Kathleen, Bruce, Zara, Richards, Linda and Boyd, Andrew (2013). The Glial Differentiation Factor Nuclear Factor One B (Nfib) Induces Differentiation and Inhibits Growth of Glioblastoma.. In: 4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO), San Francisco, United States, (27-27). Nov 21-24, 2013. doi:10.1093/neuonc/not174


Author Stringer, Brett
Day, Bryan
Barry, Guy
Piper, Michael
Jamieson, Paul
Ensbey, Kathleen
Bruce, Zara
Richards, Linda
Boyd, Andrew
Title of paper The Glial Differentiation Factor Nuclear Factor One B (Nfib) Induces Differentiation and Inhibits Growth of Glioblastoma.
Conference name 4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)
Conference location San Francisco, United States
Conference dates Nov 21-24, 2013
Journal name Neuro-Oncology   Check publisher's open access policy
Place of Publication Cary, United States
Publisher Oxford University Press
Publication Year 2013
Year available 2013
Sub-type Published abstract
DOI 10.1093/neuonc/not174
Open Access Status
ISSN 1522-8517
1523-5866
Volume 15
Issue S3
Start page 27
End page 27
Total pages 1
Collection year 2014
Language eng
Formatted Abstract/Summary
The phylogenetically-conserved vertebrate transcription factor, NFIB, is an orchestrator of glial differentiation in the developing mammalian central nervous system. We found NFIB expression to be reduced in glioblastoma (GBM), the commonest and most lethal primary adult brain cancer, so investigated what effect increased expression of NFIB had on GBM. Increased expression of NFIB in primary GBM cell lines induced expression of markers of glial differentiation, inhibited cell proliferation, reduced stem/progenitor cell growth, altered cell cycle progression and inhibited tumor growth in murine models of GBM. We thus identified NFIB to be a novel tumor suppressor gene in GBM.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: Queensland Brain Institute Publications
 
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